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Neurofibromatosis 2 (NF2) is a genetic disorder in which tumors form on the nerves of the brain and spine (the central nervous system).
See also: Neurofibromatosis 1 (NF1)
NF2; Bilateral acoustic neurofibromatosis; Central bilateral acoustic NF
Causes, incidence, and risk factors
NF2 is passed down through families in an autosomal dominant pattern. This means that if one parent has NF2, any child of that parent has a 50-50 chance of having it.
The main risk factor is having a family history of the condition.
Symptoms of NF2 include:
Signs and tests
Acoustic neuromas can be observed, or treated with surgery or radiation.
Patients may benefit from genetic counseling.
Every year, patients with NF2 should be evaluated with:
For information and support, visit www.nf.org .
Ferner RE. Neurofibromatosis 1 and neurofibromatosis 2: a twenty first century perspective. Lancet Neurol. 2007;6:340-351.
Haslam RHA. Neurocutaneous syndromes. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 596.
Reviewed by:Chad Haldeman-Englert, MD, Wake Forest School of Medicine, Department of Pediatrics, Section on Medical Genetics, Winston-Salem, NC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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