Lactate dehydrogenase test
Lactate dehydrogenase test
The lactate dehydrogenase (LDH) test measures the amount of LDH in the blood.
See also: LDH isoenzymes
LDH test; Lactic acid dehydrogenase test
How the test is performed
A blood sample is needed. For information on how this isdone, see: Venipuncture
How to prepare for the test
Your health care provider may ask you to stop taking drugs that may affect the test. Drugs that can increase LDH measurements include anesthetics, aspirin, clofibrate, fluorides, mithramycin, narcotics, and procainamide.
Why the test is performed
LDH is most often measured to check for tissue damage. The protein LDH is in many body tissues, especially the heart, liver, kidney, muscles, brain, blood cells, and lungs.
Other conditions under which the test may be done:
A typical range is 105 - 333 IU/L (international units per liter).
The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
What abnormal results mean
Higher-than-normal levels may indicate:
- Blood flow deficiency (ischemia)
- Cerebrovascular accident (such as a stroke)
- Heart attack
- Hemolytic anemia
- Infectious mononucleosis
- Liver disease (for example, hepatitis)
- Low blood pressure
- Muscle injury
- Muscular dystrophy
- New abnormal tissue formation (usually cancer)
- Tissue death
If the LDH level is raised, your doctor may order an LDH isoenzymes test.
Gallagher PG. Hemolytic anemias: red cell membrane and metabolic defects In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 164.
Gregg X, Prchal JT. Red Blood Cell Enzymopathies. In: Hoffman R, Benz EJ, Shattil SS, et al, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 45.
Reviewed by:Todd Gersten, MD, Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington; David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorousstandards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information andservices. Learn more about A.D.A.M.'s editorialpolicy, editorialprocess, and privacypolicy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch.)
The information provided herein should not be used during any medical emergency or for the diagnosis or treatmentof any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions.Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 2015 A.D.A.M., Inc. Any duplication ordistribution of the information contained herein is strictly prohibited.