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Drug Information For:


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Common Uses:

This medicine is an anticoagulant used to prevent or treat harmful blood clots.

Before Using This Medicine:

Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking apixaban, dabigatran, desirudin, or rivaroxaban. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking antihistamines (eg, diphenhydramine), antiplatelet medicines (eg, clopidogrel), dicumarol, digitalis (eg, digoxin), dipyridamole, hydroxychloroquine, injectable cephalosporins (eg, cefuroxime), injectable penicillins (eg, piperacillin, methicillin), nicotine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), salicylates (eg, aspirin), tetracyclines (eg, doxycycline), or warfarin. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a blood disorder (eg, hemophilia), liver or kidney problems, von Willebrand disease, heart problems, high blood pressure, menstrual problems, a fever or infection, allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of blood conditions, bleeding in the brain, or ulcers or other stomach problems. Tell your doctor if you have recently had or are scheduled to have brain, eye, or spinal surgery; an epidural catheter; or a spinal puncture, or you have recently had an injury. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have uncontrolled high blood pressure or low blood platelet counts. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. This medicine is usually administered as an injection at your doctor's office, hospital, or clinic. This medicine is sometimes used at home as an injection. If you are using this medicine at home, a health care professional will provide detailed instructions for its appropriate use. Ask any questions that you may have about this medicine or giving injections. Do NOT use this medicine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged. STORE THIS MEDICINE as directed on the prescription label. KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children and away from pets. IF YOU MISS A DOSE OF THIS MEDICINE, contact your doctor.


DO NOT USE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. DO NOT STOP USING THIS MEDICINE without first checking with your doctor. DO NOT USE MORE OF THIS PRODUCT THAN RECOMMENDED by your doctor, nurse, or pharmacist. Laboratory and/or medical tests, including hematocrit, platelet counts, and tests for blood in the stool, may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. THIS MEDICINE MAY REDUCE THE NUMBER OF BLOOD CELLS THAT ARE NEEDED FOR CLOTTING. To prevent bleeding, avoid situations where bruising or injury may occur. Contact your doctor immediately if you experience unusual bruising or bleeding or blood in the stools. THIS MEDICINE MAY CAUSE A SERIOUS SIDE EFFECT called heparin-induced thrombocytopenia (HIT) and Heparin-induced Thrombocytopenia and Thrombosis (HITT). These effects may occur for up to several weeks after you stop this medicine. Contact your doctor right away if you develop calf or leg pain, tenderness, or swelling; chest pain; confusion; coughing up blood; lower back pain; numbness or color change of the skin, fingers, or toes; one-sided numbness or weakness; shortness of breath; slurred speech; sudden severe headache; or vision problems. THIS MEDICINE MAY HAVE benzyl alcohol in it. Do not use products that contain benzoyl alcohol in NEWBORNS or INFANTS. It may cause serious and sometimes fatal nervous system problems and other side effects. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. This includes medicines containing aspirin, ibuprofen, or naproxen. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY, especially women. They may be more sensitive to the effects of the medicine, especially bleeding. FOR WOMEN: IF YOU BECOME PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.

Possible Side Effects:

SIDE EFFECTS that may occur while using this medicine include irritation or mild pain at the injection site. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience black, tarry, or bloody stools; blood in the urine; calf or leg pain, tenderness, or swelling; chest pain; confusion; coughing up blood; fainting; fever or chills; lower back pain; numbness or color changes of the skin, fingers, or toes; one-sided numbness or weakness; severe headache or dizziness; severe or persistent pain, swelling, or redness at the injection site; shortness of breath; slurred speech; stomach pain or swelling; unusual bruising; unusual or excessive bleeding (eg, bleeding from gums when brushing or flossing teeth, increased menstrual bleeding, unexplained vaginal bleeding, nosebleeds, excessive bleeding from cuts); vision problems; or vomit that looks like coffee grounds. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; or swelling of the mouth, face, lips, or tongue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include unexplained bleeding and bruising, stomach pain or swelling, back pain, black or tarry stools, blood in urine, vomiting blood, dizziness, and headache.

Additional Information:

DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE, as well as needles and syringes, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for proper disposal.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.