BUPROBAN 150MG ER TABLETS   Enlarge image

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Drug Information For:


Ingredient Name:

BUPROPION (bue-PROE-pee-on)

Drug Manufacturer:


Common Uses:

This medicine is an antidepressant used for helping certain patients to stop smoking cigarettes. It may also be used for other conditions as determined by your doctor.

Before Using This Medicine:

WARNING: Although this medicine is not used to treat depression, it contains the same ingredient that is in the antidepressants Aplenzin and Wellbutrin. Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using this medicine outweigh the risks. Some patients have also developed depression and certain other mental or mood problems, including suicidal thoughts or actions, while taking this medicine to help them quit smoking. FAMILY AND CAREGIVERS MUST CLOSELY WATCH patients who take this medicine. It is important to keep in close contact with the doctor. Contact the doctor at once if new, worsened, or sudden symptoms such as agitation; hostility; depressed mood; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur. Discuss any questions with the doctor. THIS MEDICINE IS NOT APPROVED FOR USE IN CHILDREN. Talk with the doctor. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE IF you are taking another medicine that contains bupropion or if you are taking or have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking amantadine, antipsychotics (eg, haloperidol, risperidone), clopidogrel, corticosteroids (eg, prednisone), cyclophosphamide, efavirenz, HIV protease inhibitors (eg, nelfinavir), insulin, levodopa, nicotine patches, oral hypoglycemics (eg, glipizide), orphenadrine, sympathomimetics (eg, pseudoephedrine), tamoxifen, theophylline, thiotepa, tiagabine, ticlopidine, carbamazepine, phenobarbital, phenytoin, rifampin, antiarrhythmics (eg, propafenone, flecainide), beta-blockers (eg, metoprolol), phenothiazines (eg, thioridazine), ritonavir, methylene blue, selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine), tricyclic antidepressants (eg, nortriptyline), or other antidepressants. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including diabetes, kidney problems, high blood pressure, heart problems (eg, congestive heart failure), increased eye pressure or glaucoma, recent heart attack, allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of seizure, head injury, tumor in the brain or spinal cord, or liver problems (eg, cirrhosis). Tell your doctor if you or a family member has a history of bipolardisorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse. Tell your doctor if you are taking nonprescription weight loss medicines or stimulants. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy). Tell your doctor if you are suddenly stopping the use of alcohol, benzodiazepines (eg, alprazolam), sedatives (medicines that make you sleepy), or seizure medicines (eg, phenobarbital) after long-term use. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.

How to Use This Medicine:

Follow the directions for taking this medicine provided by your doctor. This medicine has a MEDICATION GUIDE approved by the U.S. Food and Drug Administration. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. TAKE THIS MEDICINE by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. SWALLOW THIS MEDICINE WHOLE. Do not break, crush, divide, or chew before swallowing. STORE THIS MEDICINE at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight, light-resistant container away from heat, moisture, and light. Do not store in the bathroom. KEEP THIS MEDICINE out of the reach of children and away from pets. SEVERAL WEEKS MAY PASS BEFORE YOUR SYMPTOMS IMPROVE. Do not stop taking this medicine without checking with your doctor. It takes about 1 week for this medicine to work. You should begin taking this medicine while you are still smoking. However, you and your doctor should decide on the date that you will stop smoking during the 2nd week of taking this medicine. IF YOU HAVE NOT MADE PROGRESS TOWARDS STOPPING SMOKING BY THE 12TH WEEK, contact your doctor. If you are not able to stop smoking while using this medicine, talk to your doctor to determine why you were not successful. After the reasons have been reduced or eliminated, you should try to stop smoking again. TAKE YOUR DOSES AT THE SAME TIMES EACH DAY AT LEAST 8 HOURS APART unless directed otherwise by your doctor. This may help to decrease the risk of seizures with this medicine. IF YOU HAVE TROUBLE SLEEPING, you may be taking your dose too close to bedtime. Talk with your doctor about changing your dosing schedule. CONTINUE TO TAKE THIS MEDICINE EVEN IF YOU FEEL WELL. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, skip the missed dose. Go back to your regular dosing schedule. Do not take more than 1 dose within 8 hours. Do not take 2 doses at once.


DO NOT USE THIS MEDICINE IF you are allergic to any ingredient in this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you use this medicine. THIS MEDICINE MAY CAUSE DROWSINESS, DIZZINESS, OR BLURRED VISION. These effects may be worse if you take it with alcohol or certain medicines. Use this medicine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. CHECK WITH YOUR DOCTOR BEFORE YOU DRINK ALCOHOL OR USE MEDICINES THAT MAY CAUSE DROWSINESS while you are taking this medicine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. THIS MEDICINE MAY INCREASE YOUR RISK OF SEIZURES. Talk to your doctor to see if you may have a greater risk of seizures while taking this medicine. IF YOU ALREADY DRINK ALCOHOL OR USE SEDATIVES, do not suddenly stop them without first checking with your doctor. Suddenly stopping them may increase your seizure risk. DO NOT TAKE decongestants (eg, pseudoephedrine), stimulants, or diet pills while you are taking this medicine without first checking with your doctor. They may increase your risk of seizures. The risk of seizures may be greater if you take this medicine in high doses or for a long time. Do NOT take more than the recommended dose, change your dose, or use this medicine for longer than prescribed without checking with your doctor. CHILDREN, TEENAGERS, AND YOUNG ADULTS WHO TAKE THIS MEDICINE MAY BE AT INCREASED RISK FOR SUICIDAL THOUGHTS OR ACTIONS. Watch all patients who take this medicine closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur. THIS MEDICINE CAN BE USED TOGETHER WITH THE NICOTINE SKIN PATCHES ONLY UNDER THE SUPERVISION OF YOUR DOCTOR. Using these medicines together may raise your blood pressure. If you are already using a nicotine skin patch, your blood pressure should be checked regularly. DO NOT SMOKE IF you are using this medicine along with the nicotine skin patch or any nicotine product. STOPPING SMOKING MAY CHANGE THE AMOUNT OF CERTAIN MEDICINES (eg, theophylline, warfarin) in your blood. Be sure your doctor knows all the medicines that you are taking. THIS MEDICINE CONTAINS THE SAME INGREDIENTS AS THE ANTIDEPRESSANTS APLENZIN and WELLBUTRIN. Do not take this medicine if you are also taking Aplenzin, Wellbutrin, or other brands of bupropion. Discuss any questions or concerns with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINES, either prescription or over-the-counter, check with your doctor or pharmacist. Use this medicine with caution in the ELDERLY; they may be more sensitive to itseffects. FOR WOMEN: IF YOU BECOME PREGNANT, contact your doctor. You will need to discuss the benefits and risks of using this medicine while you are pregnant. This medicine is found in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you use this medicine, check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects:

SIDE EFFECTS that may occur while taking this medicine include anxiety; changes in appetite; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; nausea; nervousness; stomach pain; stuffy nose; trouble sleeping; vomiting; or weight changes. If they continue or are bothersome, check with your doctor. SOME PEOPLE MAY BE AT RISK FOR EYE PROBLEMS from this medicine. Your doctor may want you to have an eye exam to see if you are at risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, or swelling or redness in or around the eye. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain; confusion; changes in sexual desire or ability; dark urine; delusions; fainting; fast or irregular heartbeat; fever or chills; hallucinations; hearing problems or ringing in the ears; joint or muscle pain; menstrual changes; new or worsening mental or mood changes (eg, concentration problems, depression, panic attacks, aggressiveness, agitation, anxiety, impulsiveness, irritability, hostility, exaggerated feeling of well-being, inability to sit still); pale stools; red, swollen, blistered, or peeling skin; seizures; severe headache or dizziness; severe or persistent restlessness or trouble sleeping; severe or persistent nausea, vomiting, or stomach pain; shortness of breath; suicidal thoughts or attempts; tremor; or yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately.

Additional Information:

IT IS IMPORTANT TO FOLLOW THE PROGRAM THAT YOUR DOCTOR HAS PRESCRIBED, including behavioral changes, counseling, or support services, in order to stop smoking. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.