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Drug Information For:


Ingredient Name:

GUAIFENESIN (gwye-FEN-e-sin) and CODEINE (KOE-deen)

Drug Manufacturer:


Common Uses:

This medicine is a narcotic cough suppressant and expectorant combination used to treat cough due to colds or flu. It may also be used for other conditions as determined by your doctor.

Before Using This Medicine:

WARNING: Some children have had serious and sometimes fatal breathing problems when using codeine after surgery to remove tonsils or adenoids. Talk with your doctor for more information. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking sodium oxybate. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are also taking cimetidine, digoxin, droxidopa, HIV protease inhibitors (eg, ritonavir), naltrexone, or quinidine. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including if you have a history of an enlarged prostate gland or other prostate problems; heart problems; kidney or liver problems; a blockage of your bowel or bladder; adrenal gland problems (eg, Addison disease); an underactive thyroid; stomach problems; bowel problems (eg, chronic inflammation or ulceration of the bowel); gallbladder problems (eg, gallstones); asthma; chronic cough; lung problems (eg, chronic bronchitis, emphysema); chronic obstructive pulmonary disease (COPD); or if your cough occurs with large amounts of mucus. Tell your doctor if you have recently had any head injury, brain injury or tumor, increased pressure in the brain, infection of the brain or nervous system, epilepsy, seizures, a history of alcohol abuse, drug abuse, or suicidal thoughts or behavior, allergies; pregnancy; or breast-feeding. Tell your doctor if you have had recent abdominal surgery. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease). USE OF THIS MEDICINE IS NOT RECOMMENDED if the patient is a child and has just had surgery to remove tonsils or adenoids. Use of this medicine in children under age 2 is not recommended. Discuss with your doctor the risks and benefits of giving this medicine to your child. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.

How to Use This Medicine:

FOLLOW THE DIRECTIONS for using this medicine provided by your doctor or on the package. DO NOT EXCEED the recommended dose. TAKE THIS MEDICINE with food. TO HELP THIS MEDICINE LOOSEN CONGESTION, drink a glass of water or other liquid with each dose of medicine unless directed otherwise by your doctor. STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light. IF YOU MISS A DOSE OF THIS MEDICINE and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.


DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. DO NOT TAKE THIS MEDICINE IF YOU HAVE HAD A SEVERE ALLERGIC REACTION to codeine, hydrocodone, dihydrocodeine, or to oxycodone. A severe allergic reaction includes a severe rash, hives, breathing difficulties, or dizziness. If you have a question about whether you are allergic to this medicine or if a certain medicine contains codeine, hydrocodone, dihydrocodeine, or oxycodone, contact your doctor or pharmacist. IF YOU EXPERIENCE difficulty breathing; tightness of chest; swelling of eyelids, face, or lips; or if you develop a rash or hives, tell your doctor immediately. Do not take any more of this medicine unless your doctor tells you to do so. DO NOT EXCEED THE RECOMMENDED DOSE or take this medicine for longer than prescribed. Exceeding the recommended dose or taking this medicine for longer than prescribed may be habit-forming. IF YOUR COUGH CONTINUES for more than 7 days, or if you develop a high fever or persistent headache, check with your doctor. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you use this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. AVOID ALCOHOL while you are using this medicine. THIS MEDICINE WILL ADD TO THE EFFECTS of alcohol and other depressants (such as sleep aids or tranquilizers). Ask your pharmacist if you have questions about which medicines are depressants. THIS MEDICINE MAY CAUSE drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. THIS MEDICINE MAY CAUSE DIZZINESS, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. This includes other cough and cold medicines. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine. FOR WOMEN: THIS MEDICINE MAY CAUSE HARM to the human fetus. IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while you are taking this medicine include drowsiness, dizziness, headache, nausea, vomiting, constipation, or stomach pain. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience change in the amount of urine, facial flushing, involuntary muscle movement, mood or mental changes, or severe or persistent vomiting. CONTACT YOUR DOCTOR IMMEDIATELY if you experience fainting, irregular heartbeat, hallucinations, or slow or irregular breathing. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include slowed breathing, extreme drowsiness, deep sleep or loss of consciousness, decrease in muscle tone, cold and clammy skin, or slow pulse.

Additional Information:

If your symptoms do not improve within 5 days, if they become worse, or if you develop a high fever or persistent headache, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children and pets. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.