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Drug Information For:


Ingredient Name:

CYCLOPHOSPHAMIDE (sye-kloe-FOSS-fa-mide)

Drug Manufacturer:


Common Uses:

This medicine is an alkylating agent used to treat certain cancers. It may also be used to treat certain kidney problems (nephrotic syndrome) in children or for other conditions as determined by your doctor.

Before Using This Medicine:

Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking TNF-blocking medicines (eg, etanercept), anthracyclines (eg, doxorubicin), cytarabine, pentostatin, trastuzumab, anticoagulants (eg, warfarin), ACE inhibitors (eg, lisinopril), amiodarone, amphotericin B, azathioprine, busulfan, filgrastim, indomethacin, natalizumab, paclitaxel, pegfilgrastim, protease inhibitors (eg, ritonavir, boceprevir), thiazide diuretics (eg, hydrochlorothiazide), zidovudine, tamoxifen, or cyclosporine. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including if you have an infection, chickenpox, bone marrow problems (eg, low blood platelet levels, low red blood cell levels, low white blood cell levels), allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of heart, lung, liver, thyroid, or kidney problems. Tell your doctor if you have had an adrenal gland removed (adrenalectomy) or if you are receiving or have received chemotherapy or radiation therapy. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a urinary blockage. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. This medicine may be taken with or without food in the morning. SWALLOW THIS MEDICINE WHOLE. Do not break, crush, or chew before swallowing. DO NOT OPEN CAPSULES before swallowing. WEAR GLOVES WHEN HANDLING this medicine. Avoid contact with broken capsules and tablets. IF THIS MEDICINE gets on your skin, wash it off right away with soap and water. IF NAUSEA, VOMITING, DIARRHEA OR LOSS OF APPETITE OCCURS, ask your doctor, nurse, or pharmacist for ways to lessen these effects. DRINKING EXTRA FLUIDS AND EMPTYING your bladder regularly while you are taking this medicine is recommended. Check with your doctor for instructions. STORE THIS MEDICINE at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), away from heat, moisture, and light. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. KEEP THIS MEDICINE out of the reach of children and away from pets. IF YOU MISS A DOSE OF THIS MEDICINE, contact your doctor right away.


DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or if you are allergic to any ingredient in this product or to other similar medicines. Laboratory and/or medical tests may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are being treated with this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS OR SURGERY, tell the doctor or dentist that you are taking this medicine. THIS MEDICINE MAY CAUSE dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use this medicine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. THIS MEDICINE CAN LOWER the ability of your bone marrow to make blood cells that your body needs. This may lead to severe and sometimes fatal problems (eg, infections). Discuss any questions or concerns with your doctor. THIS MEDICINE MAY REDUCE THE NUMBER OF BLOOD CELLS NEEDED FOR CLOTTING. To prevent bleeding, avoid situations where bruising or injury may occur. DO NOT RECEIVE A LIVE VACCINE (eg, measles, mumps) while you are taking this medicine. Talk with your doctor before you receive any vaccine. SEVERE AND SOMETIMES FATAL urinary tract, heart, lung, and liver problems have been reported in patients taking this medicine. Discuss any questions or concerns with your doctor. THIS MEDICINE MAY DECREASE your body's ability to heal wounds. Discuss any questions or concerns with your doctor. THIS MEDICINE MAY INCREASE your chance of developing a second cancer, sometimes even years after stopping treatment with this medicine. Discuss any questions or concerns with your doctor. THIS MEDICINE MAY CAUSE infertility that is sometimes permanent. Discuss any questions or concerns with your doctor. LOW BLOOD SODIUM LEVELS MAY OCCUR from treatment with this medicine. In severe cases, this can be deadly. Discuss any questions or concerns with your doctor. MEN WHO TAKE THIS MEDICINE must use a condom during sexual contact with women who are pregnant or may become pregnant. Do this during treatment with this medicine and for at least 4 months after treatment is stopped. If your female partner becomes pregnant, contact your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine. FOR WOMEN: If you are able to become pregnant, you must use an effective form of birth control while you take this medicine and for 1 year after you stop treatment. If you have questions about effective birth control, talk with your doctor. THIS MEDICINE MAY CAUSE HARM to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks ofusing this medicine while you are pregnant. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while using this medicine include color change in skin, nausea, vomiting, loss of appetite, diarrhea, absence of menstrual periods, stomach discomfort or pain, texture change in nails, or hair loss. If they continue or are bothersome, check with your doctor. THIS MEDICINE LOWERS YOUR RESISTANCE to infection. To prevent infection, avoid contact with people who have colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first. Tell your doctor if you notice signs of infection like fever, chills, cough, sore throat, rash, or burning or painful urination. CONTACT YOUR DOCTOR IMMEDIATELY if you experience bloody, black, or tarry stools; chest pain; fainting; fast, slow, or irregular heartbeat; red, swollen, or blistered skin; severe or persistent dizziness; severe or persistent stomach pain; shortness of breath; sores in the mouth or on the tongue; sudden, unusual weight gain; swelling of the hands, ankles, or feet; symptoms of kidney or urinary tract problems (eg, blood in the urine, change in the amount of urine produced, lower back pain, red or pink urine); symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, severe stomach pain, yellowing of the skin or eyes); symptoms of low blood sodium levels (eg, confusion, decreased coordination, fainting, hallucinations, headache, memory problems, mental or mood changes, seizures, sluggishness, trouble concentrating, weakness); unusual bruising or bleeding; or unusual or severe tiredness or weakness. ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If overdose is suspected, contact your local poison control center or emergency room immediately.

Additional Information:

DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF YOU WILL BE USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, be sure to obtain necessary refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.