FENTANYL 75MCG/HR  PATCH   Enlarge image

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Drug Information For:


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Common Uses:

This medicine is a narcotic (opioid) pain medicine used to manage severe chronic pain. This medicine is only for use when continuous, around-the-clock treatment is needed for a long time. It is only for use when other pain treatments do not treat your pain well enough or you cannot take them. This medicine should only be used by patients who have already been taking other narcotic pain medicine on a regular schedule and are tolerant to its effects.

Before Using This Medicine:

WARNING: This medicine is a narcotic pain medicine that may become habit-forming. Misuse or abuse by placing it in the mouth or chewing, swallowing, injecting, or snorting it can lead to overdose and death. THIS MEDICINE MAY CAUSE severe and sometimes fatal breathing problems. The risk may be greater when you start this drug or with any dose increase. It should not be used if you have not already been taking and are tolerant to narcotic pain medicine, right after surgery if you are not already using narcotic pain medicines, for only occasional or "as-needed" pain relief, or if the pain is mild or not expected to last for a long time. The risk of this medicine's side effects may be increased if you also take or have recently stopped certain other medicines (eg, amiodarone, amprenavir, aprepitant, carbamazepine, clarithromycin, diltiazem, erythromycin, fluconazole, fosamprenavir, itraconazole, ketoconazole, nefazodone, nelfinavir, phenytoin, rifampin, ritonavir, troleandomycin, verapamil) or if you eat grapefruit or drink grapefruit juice. Ask your doctor or pharmacist if you have questions about which medicines may increase the risk of breathing problems. Contact your doctor right away if you experience slow, shallow, or difficult breathing. ACCIDENTAL EXPOSURE TO A NEW OR USED PATCH (either on the skin or in the mouth) may cause serious and sometimes fatal side effects, especially in children. Keep this medicine out of the reach of children. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT USE THIS MEDICINE if you also take buprenorphine, mifepristone, a mixed agonist/antagonist pain medicine (eg, butorphanol, nalbuphine, pentazocine), sibutramine, sodium oxybate, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), or if you have taken an MAOI within the past 14 days. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking amiodarone, anticholinergics (eg, scopolamine), aprepitant, azole antifungals (eg, ketoconazole), benzodiazepines (eg, alprazolam), crizotinib, diltiazem, fosaprepitant, macrolide antibiotics (eg, erythromycin), naltrexone, other narcotic medicines (eg, oxycodone), phenothiazines (eg, chlorpromazine), rifamycins (eg, rifampin), telithromycin, verapamil, or medicine for HIV or mental or mood problems (eg, depression). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of lung or breathing problems; sleep apnea; scoliosis; heart problems (eg, slow or irregular heartbeat); high blood carbon dioxide levels; low blood oxygen levels; liver, kidney, gallbladder, or thyroid problems; pancreas problems; urinary blockage or trouble urinating; stomach or bowel problems (eg, blockage); seizures; suicidal thoughts or actions; allergies (eg, adhesives);pregnancy; or breast-feeding. Tell your doctor if you have severe drowsiness, growths in the brain (eg, tumors), a recent head injury, low blood pressure, dehydration, low blood volume, constipation, stomach pain, poor health, or a fever. Tell your doctor if you or a member of your family has a history of mental or mood problems (eg, depression), or alcohol or other substance abuse or dependence; you drink alcohol or have symptoms of alcohol withdrawal; or you have been very ill, are very overweight, have recently had or will be having surgery (eg, stomach or bowel surgery), or will be having an MRI. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have difficult, shallow, or slowed breathing; severe lung problems (eg, severe asthma) or you are having an asthma attack; severe liver or kidney problems; narrowing of the stomach or bowels or known or suspected stomach or bowel blockage (eg, paralytic ileus); or increased pressure in the brain. Contact your doctor or pharmacist if you have any questions about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. AN ADDITIONAL PATIENT INFORMATION LEAFLET is available with this medicine. In the United States, the patient leaflet is a MEDICATION GUIDE approved by the U.S. Food and Drug Administration along with detailed instructions for use. Read them carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. APPLY THIS MEDICINE to the skin only. Do not chew, swallow, or put this medicine in your mouth. BEFORE USING THIS MEDICINE, clip (do not shave) any hair at the application site. Clean the area with clear water and allow the skin to dry completely. Do not use soaps, oils, lotions, alcohol, or any other liquid that could irritate or otherwise affect the skin. APPLY THIS MEDICINE right after removing it from the sealed package. Do not use a patch if the package is not sealed. Do not apply a patch that has been cut or damaged in any way. THE PATCH should be applied to a dry, smooth, undamaged, nonirradiated section of skin on a flat surface (eg, chest, back, flank, upper arm). In young children or patients with mental impairment, place the patch on their upper back to decrease the chance that they will remove the patch and put it in their mouths. Press firmly for 30 seconds to make sure the patch stays in place. Check to see that the edges of the patch are stuck to the skin. Wash your hands after applying or removing the patch. IF THE PATCH DOES NOT STICK, you may tape only the edges with first aid tape or cover the patch with a special type of clear adhesive film dressing (eg, Bioclusive, Tegaderm). Do not cover the patch with any other bandage or tape. Ask your doctor if you are unsure of what type of dressing you can use. A PATCH MAY BE WORN continuously for 72 hours or as directed by your doctor. If pain relief for more than 72 hours is needed, apply a new patch to a different skin area after removing the old patch. Do not wear more than 1 patch at a time unless your doctor tells you otherwise. If the patch falls off before 72 hours have passed, apply a new patch to a different skin site. PREVENT OTHERS FROM COMING INTO CONTACT with this medicine (eg, while hugging, sharing the same bed, accidental sitting on a patch, accidental exposure of a caregiver while applying or removing a patch). CHECK WITH YOUR DOCTOR BEFORE EATING GRAPEFRUIT or drinking grapefruit juice while taking this medicine. IF YOUR PAIN CONTINUES or becomes worse or if you have side effects that concern you, contact your doctor. STORE THIS MEDICINE at room temperature below 77 degrees F (25 degrees C) in its original sealed pouch, away from heat, moisture, and light. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. KEEP THIS MEDICINE out of the reach of children and away from pets. DISPOSE OF USED PATCHES (including patches that have fallen off) and unused patchesthat are no longer needed according to the instructions in the additional patient leaflet that comes with this medicine. Contact your pharmacist if you have any questions about how to dispose of this medicine. IF YOU FORGET TO CHANGE YOUR PATCH on the day it is due, change the patch as soon as you remember. DO NOT double your dose to catch up.


DO NOT USE THIS MEDICINE if you are allergic to any ingredient in this product. BEFORE USING THIS MEDICINE, tell you doctor if you have had an allergic reaction to any other narcotic pain medicine (eg, codeine). DO NOT EXPOSE THE PATCH APPLICATION SITE or surrounding areas to direct sources of heat, such as electric blankets, heating pads, heat or tanning lamps, saunas, hot tubs, or heated waterbeds. Avoid sunbathing; long, hot baths; or other sources of heat to the body. Avoid activities that can increase body temperature. Tell your doctor if you develop increased body temperature (eg, due to exercise) or a fever. If using this medicine for an extended period of time, DO NOT SUDDENLY STOP taking this medicine without your doctor's approval. When used for an extended period of time, this medicine may not work as well and may require different dosing. Some conditions may become worse when the medicine is suddenly stopped. Your dose may need to be slowly lowered to avoid side effects. DO NOT EXCEED THE RECOMMENDED DOSE, change the patch more often than directed, or use this medicine for longer than prescribed. Exceeding the recommended dose or taking this medicine for longer than prescribed may be habit-forming. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, emergency care, or surgery, tell the doctor or dentist that you are using this medicine. DO NOT DRINK ALCOHOL or take medicines (prescription or nonprescription) that contain alcohol while using this medicine. Check with your pharmacist if you have questions about whether any of your medicines contain alcohol. CHECK WITH YOUR DOCTOR before using medicines that may cause drowsiness while using this medicine; the risk of severe drowsiness or breathing problems may be increased. Ask your pharmacist if you have questions about which medicines may increase the risk of these effects. ACCIDENTAL EXPOSURE TO A NEW OR USED PATCH (either by getting it on the skin or in the mouth) may cause serious and sometimes fatal side effects, especially in children. Used patches still have a lot of medicine inside them. Keep this medicine out of the reach of children. SEEK EMERGENCY MEDICAL CARE RIGHT AWAY for anyone who gets a new or used patch in the mouth. If a new or used patch accidentally sticks to the skin of another person, remove the patch from their skin immediately, wash the exposed area of skin with water, and seek medical attention. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION SHOULD BE USED IN THE ELDERLY; they may be more sensitive to the effects of this medicine. DO NOT use in children under 2 years old. FOR WOMEN: IF YOU THINK YOU MAY BE PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. Long-term use of this medicine during pregnancy may cause dependence in the unborn baby. This can lead to withdrawal inthe newborn, which can be life-threatening. THIS MEDICINE IS FOUND IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while using this medicine include diarrhea; dizziness; drowsiness; dry mouth; feeling cold; headache; loss of appetite; mild itching, redness, or discomfort at the skin application site; mild stomach pain; nausea; sweating; tiredness; trouble sleeping; or vomiting. If they continue or are bothersome, check with your doctor. THIS MEDICINE MAY CAUSE CONSTIPATION. Talk with your doctor or pharmacist about taking a stool softener or laxative to prevent constipation. It is also important to maintain a diet adequate in fiber, drink plenty of water, and exercise to prevent constipation. If you become constipated while taking this medicine, talk with your doctor or pharmacist. THIS MEDICINE MAY CAUSE DIZZINESS, drowsiness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. THESE EFFECTS MAY BE WORSE if you take it with alcohol or certain medicines. Do not drive or perform other possibly unsafe tasks until you know how you react to it. CONTACT YOUR DOCTOR IMMEDIATELY if you experience abnormal sighing; bluish skin or nails; burning, numbness, or tingling; chest pain; cold, clammy skin; confusion; difficulty urinating; difficulty talking, thinking, or walking; difficult, shallow, or slow breathing; fainting; fast, slow, or irregular heartbeat; hallucinations; mood or mental changes (eg, anxiety, depression); memory problems; muscle spasms; red, swollen, blistered, or peeling skin; seizures; severe or persistent constipation, stomach pain, or vomiting; severe or persistent dizziness, drowsiness, headache, or lightheadedness; shortness of breath; swelling of the hands, ankles, or feet; tremor; unusual tiredness or weakness; vision problems (eg, blurred vision). AN ALLERGIC REACTION TO THIS MEDICINE is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; or unusual hoarseness. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


IF OVERDOSE IS SUSPECTED, remove the patch and contact your local poison control center or emergency room immediately. Symptoms of overdose may include bluish skin or nails; cold and clammy skin; coma; confusion; difficult, shallow, or slow breathing; fainting; hallucinations; limp muscles; pinpoint or enlarged pupils; seizures; severe drowsiness, dizziness, or lightheadedness; shortness of breath; slow or irregular heartbeat; trouble thinking, talking, or walking; or unusual tiredness.

Additional Information:

THE PATCH CONTAINS A STRONG NARCOTIC PAIN MEDICINE (similar to morphine, hydromorphone, methadone, oxycodone, and oxymorphone) in the form of a gel. If the gel leaks from the patch at any time, do not touch the gel. If you have unintended contact with the gel, immediately wash the affected area with large amounts of water only. If you have concerns, speak with your pharmacist or doctor for further instructions. DO NOT CARRY the original sealed pouch containing this medicine in your pocket. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF YOU WILL BE USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, be sure to obtain a new prescription before your supply runs out. PROPERLY DISPOSE OF ANY UNUSED PATCHES remaining from a prescription as soon as they are no longer needed. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.