AZATHIOPRINE 50MG TABLETS
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IMURAN 50MG TABLETS
Ingredient Name: AZATHIOPRINE (ay-za-THYE-oh-preen)
Drug Manufacturer: PROMETHEUS
Common Uses: This medicine is an antimetabolite used in combination with other medicines to help prevent rejection after a kidney transplant. It may also be used to treat signs and symptoms of active rheumatoid arthritis and other conditions as determined by your doctor.
Before Using This Medicine: WARNING: LONG-TERM USE OF THIS MEDICINE INCREASES THE RISK OF DEVELOPING CERTAIN TYPES OF CANCERS (eg, leukemia, lymphoma, skin cancer). A rare type of cancer called hepatosplenic T-cell lymphoma (HSTCL) has been reported in patients treated with this medicine. These cases have been fatal. Most of these cases occurred in teenagers and young adults who had Crohn disease or ulcerative colitis. Some patients who developed this cancer were using this medicine along with certain other medicines called TNF blockers (eg, infliximab). Tell your doctor if you have or ever had any type of cancer. This medicine may also cause serious blood disorders (eg, anemias, low white blood cell or platelet levels). Discuss any questions or concerns with your doctor. CONTACT YOUR DOCTOR AT ONCE if you develop changes in the appearance or size of a mole; easy bruising or bleeding; unusual growths; unusual lumps or swelling (eg, in your neck, armpit, or groin); persistent unexplained itching; night sweats; signs of infection (eg, fever, chills, persistent sore throat); stomach pain or tenderness; unusual tiredness or weakness; or unexplained weight loss. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking febuxostat or mercaptopurine. DO NOT TAKE THIS MEDICINE if you have rheumatoid arthritis and have taken alkylating agents (eg, cyclophosphamide, chlorambucil, melphalan) in the past. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking alkylating agents (eg, cyclophosphamide, chlorambucil, melphalan), allopurinol, aminosalicylates (eg, mesalazine, olsalazine, sulfasalazine), angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril, lisinopril), anticoagulants (eg, warfarin), disease-modifying antirheumatic drugs (DMARDs) (eg, methotrexate, adalimumab), doxorubicin, ribavirin, TNF blockers (eg, certolizumab, etanercept), or trimethoprim/sulfamethoxazole . DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including an infection, kidney or liver problems, certain bowel problems (eg, Crohn disease, ulcerative colitis), certain enzyme deficiencies (thiopurine methyltransferase / TPMT, xanthine oxidase), allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of frequent, recurrent, or prolonged infections; cancer; bone marrow problems; anemia; low white blood cell or platelet levels; or unusual bruising or bleeding. Tell your doctor if you have recently had a blood transfusion or if you have recently had or are scheduled to receive a vaccination. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
How to Use This Medicine: Follow the directions for using this medicine provided by your doctor. TAKE THIS MEDICINE by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. ASK YOUR DOCTOR if you should follow any special guidelines for handling this medicine. STORE THIS MEDICINE at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), in a tightly closed container, away from heat, moisture, and light. Do not store in the bathroom. KEEP THIS MEDICINE out of the reach of children and away from pets. IF THIS MEDICINE IS NO LONGER NEEDED, ask your doctor or pharmacist how to dispose of it properly. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.
Cautions: DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. Laboratory and/or medical tests, including liver function tests, complete blood counts, and TPMT enzyme activity may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. CHECK WITH YOUR DOCTOR BEFORE HAVING ANY IMMUNIZATIONS (VACCINATIONS) while you are using this medicine. THIS MEDICINE MAY LOWER YOUR RESISTANCE TO INFECTION. Prevent infection by avoiding contact with people with infection. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first. THIS MEDICINE MAY REDUCE THE NUMBER OF BLOOD CELLS NEEDED FOR CLOTTING. To prevent bleeding, avoid situations where bruising or injury may occur. CONTACT YOUR DOCTOR IMMEDIATELY if you develop severe nausea and vomiting. This may occur with or without diarrhea, rash, fever, muscle pain, dizziness, fainting, or unusual tiredness. If this reaction occurs, it usually happens within the first several weeks of therapy. THIS MEDICINE MAY INCREASE YOUR RISK of developing a tumor or other cancer. Contact your doctor at once if you notice any unusual growths or lumps. To decrease your risk for developing skin cancer, avoid the sun, sunlamps, or tanning booths. Use a sunscreen with a high protection factor and wear protective clothing if you must be outside for more than a short time. Discuss any questions or concerns with your doctor. AN ENZYME CALLED TPMT helps to break this medicine down in the body. Infrequently, some patients may have decreased TPMT enzyme activity. This may increase the risk of developing serious side effects (such as severe bone marrow problems). Patients with decreased TPMT activity may need a lower dose of this medicine. Discuss any questions or concerns with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. FOR WOMEN: IF YOU ARE ABLE TO BECOME PREGNANT, talk with your doctor or pharmacist about the use of effective birth control while taking this medicine. THIS MEDICINE HAS BEEN SHOWN TO CAUSE HARM to the human fetus. Avoid becoming pregnant while you are taking this medicine. IF YOU THINK YOU MAY BE PREGNANT, contact your doctor immediately. This medicine should not be used to treat rheumatoid arthritis in pregnant women. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine.
Possible Side Effects: SIDE EFFECTS that may occur while you are taking this medicine include mild nausea or vomiting. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain or tightness; dark, tarry, or bloody stools; unusual bleeding or bruising; fatty stools; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, right-sided stomach pain, yellowing of the eyes or skin); symptoms of infection (eg, chills, fever, persistent sore throat; increased or painful urination; warm, red, swollen, or painful skin); severe or persistent nausea, vomiting, or diarrhea; dizziness; muscle or joint pain or aches; painful red bumps or blisters on the arms, face, neck, or back; shortness of breath; stomach pain; unusual growths or lumps; or unusual weakness or tiredness. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; or swelling of the mouth, face, lips, or tongue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Overdose: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include fever, chills, or sore throat; or severe or persistent nausea, vomiting, or diarrhea.
Additional Information: DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.
Copyright 2012 Wolters Kluwer Health, Inc.
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