LO LOESTRIN FE TABLETS 28'S   Enlarge image

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Drug Information For:


Ingredient Name:

NORETHINDRONE (nor-eth-IN-drone), ETHINYL ESTRADIOL (ETH-in-il ess-tra-DYE-ole), and FERROUS FUMARATE (FER-uhs FYOO-mar-ate)

Drug Manufacturer:


Common Uses:

This medicine is a progesterone and estrogen combination birth control pill that also contains iron. It is used to prevent pregnancy. It may also be used to treat other conditions as determined by your doctor.

Before Using This Medicine:

WARNING: CIGARETTE SMOKING INCREASES THE RISK OF SERIOUS HEART PROBLEMS associated with use of this medicine. This risk increases with age and with heavy smoking. Women who are more than 35 years old have a greater risk. WOMEN WHO ARE OLDER THAN 35 YEARS OLD AND SMOKE should not use this medicine. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. AN ADDITIONAL FORM OF BIRTH CONTROL may be needed if you are taking acitretin, aprepitant, armodafinil, azole antifungals (eg, ketoconazole), barbiturates (eg, phenobarbital), bosentan, carbamazepine, felbamate, griseofulvin, HIV protease inhibitors (eg, ritonavir), hydantoins (eg, phenytoin), modafinil, non-nucleoside reverse transcriptase inhibitors (NNRTIs) (eg, efavirenz, nevirapine), oxcarbazepine, penicillins (eg, ampicillin), phenylbutazone, pioglitazone, rifamycins (eg, rifampin), rufinamide, St. John's wort, tetracyclines (eg, doxycycline), topiramate, or troglitazone. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking corticosteroids (eg, prednisone), penicillamine, theophylline, tizanidine, tranexamic acid, troleandomycin, or certain medicines for seizures (eg, lamotrigine, valproic acid). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of endometriosis, growths in the uterus, abnormal mammogram, irregular menstrual periods, abnormal vaginal bleeding, a lump in the breast, fibrocystic breast disease, diabetes or high blood sugar, gallbladder problems, migraines or severe or persistent headaches, heart problems (eg, heart failure, angina), high blood pressure, high blood cholesterol or lipid levels, kidney or liver problems, blood or bleeding problems (eg, porphyria), mental or mood problems (eg, depression), lupus, high blood calcium levels, chloasma (dark skin patches), chorea (jerky, involuntary movements of the face, arms, or legs), varicose veins, pancreas problems, seizures, yellowing of the eyes or skin caused by pregnancy or prior birth control use, a condition called hereditary angioedema, allergies, pregnancy, or breast-feeding. TELL YOUR DOCTOR if you smoke, are very overweight, have fluid retention or swelling problems, are past menopause, or if a member of your family has a history of high triglyceride levels or breast cancer. TELL YOUR DOCTOR if you will be having surgery or will be confined to a bed or a chair for a long period of time. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have certain heart problems (eg, heart valve problems, certain types of irregular heartbeat); certain types of migraines or headaches; diabetes that affects circulation, nerves, eyes, or kidneys;liver disease; liver tumors; uncontrolled high blood pressure; or undiagnosed abnormal vaginal bleeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of blood clotting problems; severe blood clots (eg, in the lungs, legs, or eyes); certain blood vessel problems (eg, in the brain or heart, bleeding in the brain, heart attack, stroke); breast cancer; endometrial, cervical, or vaginal cancer; or estrogen-dependent growths. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have had surgery and are or will be confined to a bed or a chair for an extended period of time, if you are over 35 years old and you smoke, or if you are pregnant or think you may be pregnant. USE OF THIS MEDICINE IN CHILDREN who have not yet had their first menstrual period is not recommended. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. AN ADDITIONAL PATIENT INFORMATION LEAFLET is available with this medicine. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. TALK WITH YOUR DOCTOR about how you should start to take your first pack of this medicine. IF YOU BEGIN TO TAKE THIS MEDICINE during the first 24 hours of your period, you do not need to use an extra form of birth control. If you begin this medicine on the Sunday after your period starts, you will need to use an extra form of birth control for the first 7 days of your pack. IF YOU ARE SWITCHING FROM ANOTHER BIRTH CONTROL PILL to this medicine, start this medicine on the same day that you would have started a new pack of your previous birth control pills. Talk with your doctor if you have any questions about how to switch from another form of hormonal birth control (eg, patch, vaginal ring) to this medicine. THIS MEDICINE MAY BE TAKEN ON AN EMPTY STOMACH OR WITH FOOD. ON THE DAYS YOU TAKE THE BROWN TABLETS (iron), certain other medicines should not be taken at the same time. If you take antacids, bisphosphonates (eg, etidronate), cephalosporins (eg, cefdinir), methyldopa, quinolones (eg, ciprofloxacin), tetracyclines (eg, minocycline), thyroid hormones (eg, levothyroxine), or thrombopoietin mimetics (eg, eltrombopag), ask your doctor or pharmacist how to take them with the iron tablets. STORE THIS MEDICINE at 77 degrees F (25 degrees C), away from heat and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. KEEP THIS MEDICINE out of the reach of children and away from pets. Take the tablets in the order directed on the blister pack. AFTER TAKING THE LAST PILL in the pack, start taking the first pill from a new pack the very next day. FOR THIS MEDICINE TO BE EFFECTIVE, it must be taken every day. Do not skip doses even if you do not have sex very often. Do not skip pills if you are spotting, bleeding, or nauseous. If you have these side effects and they do not go away, check with your doctor. SEVERE VOMITING OR DIARRHEA may decrease this medicine's effectiveness. Talk with your doctor about what to do if severe vomiting or diarrhea occurs while you take this medicine. If you vomit or have diarrhea within 3 to 4 hours after you take this medicine, this should be considered a missed dose. IF YOU MISS 1 DOSE OF THIS MEDICINE, take it as soon as you remember. Take your next dose at the regular time. This means you may take 2 doses on the same day. You do not need to use a backup form of birth control if you only miss 1 pill. If you miss more than 1 dose, read the extra patient leaflet that comes with this medicine or contact your doctor for instructions. YOU MUST USE A BACKUP FORM of birth control (eg, condoms) if you miss more than 1 dose. If you are not sure how to handle misseddoses, use an extra form of birth control (eg, condoms) and talk with your doctor. If you have any questions, contact your doctor, nurse, or pharmacist.


DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. BLEEDING OR SPOTTING may occur while taking this medicine, especially during the first 3 months. Do not stop taking this medicine if this occurs. If bleeding or spotting is persistent, or if it occurs after menstrual cycles that were previously regular, contact your doctor. Lab and/or medical tests may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you use this medicine. EXAMINE YOUR BREASTS monthly as directed by your doctor. Report any lumps right away. THIS MEDICINE MAY INCREASE THE RISK OF STROKE, heart attack, blood clots, high blood pressure, or similar problems. The risk is greater if you smoke. Do not smoke or use other tobacco products while taking this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. If possible, this medicine should be stopped at least 4 weeks before surgery or any time you might be confined to a bed or chair for a long period of time (eg, long plane flight, bedrest, lengthy illness). YOU SHOULD USUALLY NOT TAKE THIS MEDICINE within 4 weeks after giving birth or after a second-trimester abortion. Talk with your doctor about how to start taking this medicine in these instances. IF YOU START TO TAKE THIS MEDICINE AFTER GIVING BIRTH and you have not yet had a period, use an extra form of birth control for 7 days after you start to take this medicine. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. THE EFFECTIVENESS OF THIS MEDICINE MAY BE DECREASED by certain medicines (eg, antibiotics, medicines for seizures, St. John's wort) or conditions (eg, vomiting, diarrhea). This could cause breakthrough bleeding or increase the risk of an unplanned pregnancy if you have sex. To prevent pregnancy while taking these medicines, use an extra form of birth control (eg, condoms). You may also need to use an extra form of birth control for a period of time after you stop taking these medicines. Talk with your doctor or pharmacist for more information. IF YOU MISS more than 2 periods in a row, or if you miss 1 period when you have not taken your pills correctly, contact your doctor. Also, if you have morning sickness or unusual breast tenderness, contact your doctor. You may be pregnant if any of these occur. DO NOT TAKE THIS MEDICINE if you are pregnant. IF YOU THINK YOU MAY BE PREGNANT, contact your doctor immediately. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine. IF YOU HAVE DIABETES, this medicine may affect your blood sugar. Check bloodsugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while taking this medicine include bleeding or spotting between menstrual periods, breast tenderness, headache, or nausea. If they continue or are bothersome, check with your doctor. THIS MEDICINE MAY CAUSE dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths. IF YOU WEAR CONTACT LENSES and you develop problems with them, contact your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience a missed menstrual period; breast pain, lump, or discharge; calf or leg pain, swelling, or tenderness; change in amount of urine produced; chest pain or heaviness; confusion; coughing up blood; fainting; irregular heartbeat; left-sided jaw, neck, shoulder, or arm pain; mental or mood changes (eg, depression); migraines; numbness of an arm or leg; one-sided weakness; persistent, severe, or recurring headache or dizziness; persistent vaginal spotting; severe or persistent trouble sleeping; severe stomach pain or tenderness; shortness of breath; slurred speech; sudden, severe vomiting; swelling of the fingers, hands, legs, or ankles; symptoms of liver problems (eg, yellowing of the skin or eyes, fever, dark urine, pale stools, loss of appetite); unusual or severe vaginal bleeding; unusual tiredness or weakness; vaginal odor, irritation, or discharge; or vision changes (eg, sudden vision loss, double vision). AN ALLERGIC REACTION TO THIS MEDICINE is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If overdose is suspected contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe nausea or vomiting, or unexplained vaginal bleeding.

Additional Information:

USE OF THIS MEDICINE WILL NOT PREVENT the spread of HIV or other sexually transmitted diseases (STDs) to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have an HIV infection or an STD. YOU MAY EXPERIENCE A DELAY in being able to become pregnant after stopping this medicine, especially if you had irregular periods before starting this medicine. Discuss any concerns with your doctor or pharmacist. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out. Your chance of becoming pregnant may be increased if you do not take this medicine every day as directed. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2014 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.