NIFEDICAL XL (ER) 30MG TABLETS   Enlarge image

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Drug Information For:


Ingredient Name:

NIFEDIPINE (nye-FED-i-peen)

Drug Manufacturer:


Common Uses:

This medicine is a calcium channel blocker used to treat high blood pressure. Some brands are also used to control angina (chest pain). It may also be used to treat other conditions as determined by your doctor.

Before Using This Medicine:

Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking a barbiturate (eg, phenobarbital), carbamazepine, a hydantoin (eg, phenytoin), a rifamycin (eg, rifampin, rifabutin), or St. John's wort. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking alpha blockers (eg, doxazosin), beta-blockers (eg, propranolol), diuretics (eg, hydrochlorothiazide, furosemide), methyldopa, phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil, tadalafil), acarbose, azole antifungals (eg, ketoconazole, fluconazole), calcium channel blockers (eg, diltiazem, verapamil), cimetidine, fluoxetine, HIV protease inhibitors (eg, ritonavir, saquinavir), imatinib, macrolide antibiotics (eg, erythromycin, clarithromycin), nefazodone, streptogramins (eg, quinupristin/dalfopristin), valproic acid, cyclosporine, digoxin, ketanserin, lithium, tacrolimus, theophylline, vinca alkaloids (eg, vincristine), or quinidine. Tell your doctor if you take other medicines to lower your blood pressure. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of angina, heart blood vessel problems, or other heart problems (eg, aortic stenosis; congestive heart failure; heart attack; fast, slow, or irregular heartbeat); high or low blood pressure; liver problems (eg, cirrhosis); kidney problems; swelling of the arms or legs; esophageal, stomach, or bowel narrowing (stricture); fluid in your lungs; allergies; pregnancy; or breast-feeding. Tell your doctor if you have recently had or will be having surgery; or if you have recently stopped taking a beta-blocker (eg, propranolol). USE OF THIS MEDICINE IS NOT RECOMMENDED if you have very low blood pressure or shock due to heart problems, or if you have had a heart attack within the past 2 weeks. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. SWALLOW WHOLE. Do not break, crush, or chew before swallowing. Check with your pharmacist about how to take this medicine with food. DO NOT EAT GRAPEFRUIT OR DRINK GRAPEFRUIT JUICE while you are using this medicine. STORE THIS MEDICINE at room temperature below 86 degrees F (30 degrees C) in a tightly-closed container, away from heat, moisture, and light. KEEP THIS MEDICINE out of the reach of children and away from pets. DO NOT SUDDENLY STOP TAKING THIS MEDICINE without checking with your doctor. If you need to stop this medicine, your doctor may gradually lower your dose. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.


DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or if you are allergic to any ingredient in this product. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. Proper dental care is important while you are taking this medicine. Brush and floss your teeth and visit the dentist regularly. THIS MEDICINE MAY CAUSE DIZZINESS, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of these effects. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. RARELY, THERE HAVE BEEN REPORTS OF ESOPHAGEAL, STOMACH, OR BOWEL BLOCKAGE in patients taking this medicine. The risk may be greater if you have constipation, diabetes, gastroesophageal reflux disease (GERD), obesity, stomach or bowel problems (eg, blockage, ileus, narrowing), underactive thyroid, or a history of stomach or bowel surgery (eg, colostomy, gastric bypass) or colon cancer. The risk may also be greater if you take this medicine with certain other medicines (eg, anticholinergics, H2-histamine blockers, laxatives, levothyroxine, nonsteroidal anti-inflammatory drugs / NSAIDs, opiates). Cases of ulcers caused by this medicine getting stuck in the stomach or bowels have also been reported in patients using this medicine. Tell your doctor if you experience bloating, severe constipation, stomach pain or cramps, difficult or painful swallowing, fever, loss of appetite, or vomiting. Discuss any questions or concerns with your doctor. PATIENTS BEING TREATED FOR HIGH BLOOD PRESSURE often feel tired or run down for a few weeks after beginning therapy. Continue taking your medicine even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms. YOU MAY NOTICE UNDISSOLVED PARTS OF THIS MEDICINE IN YOUR STOOL with some brands of this medicine. This is normal and not a cause for concern. IF YOUR DOCTOR HAS INSTRUCTED you to check your blood pressure regularly, be sure to do so. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. This includes medicines that contain stimulants, such as certain diet pills and certain cold medicines. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine. FOR WOMEN: IF YOU BECOME PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED in breast milk. IF YOUARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.

Possible Side Effects:

SIDE EFFECTS that may occur while taking this medicine include constipation; cough; dizziness; flushing; giddiness; headache; heartburn; heat sensation; lightheadedness; muscle cramps; nausea; nervousness; tiredness; weakness. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience fainting; fever, chills, or persistent sore throat; mental or mood changes; new or worsening chest pain (eg, longer, more often, more severe); red, swollen, blistered, or peeling skin; severe or persistent dizziness or light-headedness; shortness of breath; slow, fast, or irregular heartbeat; sudden, unusual weight gain; swelling of the arms or legs; symptoms of heart attack (eg, chest, jaw, or left arm pain; numbness of an arm or leg; sudden, severe headache or vomiting); tender, bleeding, or swollen gums; tremors; unusual bruising or bleeding; unusual tiredness or weakness; vision problems; wheezing; yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include fainting; loss of consciousness; rapid, slow, or irregular heartbeat; or severe dizziness or light-headedness.

Additional Information:

DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF YOU WILL BE USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, be sure to obtain necessary refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2014 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.