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Drug Information For:
PERPHENAZINE 2MG TABLETS
Ingredient Name:PERPHENAZINE (per-FEN-a-zeen)
Common Uses:This medicine is a phenothiazine used to treat schizophrenia. It is also used to treat severe nausea and vomiting. It may also be used for other conditions as determined by your doctor.
Before Using This Medicine:WARNING: THIS MEDICINE IS AN ANTIPSYCHOTIC. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. This medicine is not approved to treat mental problems caused by dementia. Discuss any questions or concerns with your doctor. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking astemizole, cabergoline, cisapride, metoclopramide, pergolide, terfenadine, or tramadol. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking other prescription and nonprescription medicines (eg, used for allergies, blood clotting problems, cancer, infections, inflammation, aches and pains, heart problems, high blood pressure, high cholesterol, irregular heartbeat, mental or mood problems, nausea or vomiting, Parkinson disease, seizures, stomach or bowel problems, overactive bladder), multivitamin products, or herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, gingko, St. John's wort). Tell your doctor if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat or may interact with this medicine. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including asthma, a lung infection, or other lung or breathing problems (eg, emphysema); increased pressure in the eyes or glaucoma, or if you are at risk of glaucoma; Alzheimer disease; dementia; Parkinson disease; Reye syndrome; poor health; allergies; pregnancy; or breast-feeding. Tell your doctor if you have a history of heart problems (eg, angina, mitral valve problems), high or low blood pressure, blood problems (eg, anemia, porphyria), bone marrow problems (eg, low white blood cell count), diabetes, liver problems (eg, cirrhosis), kidney problems, neuroleptic malignant syndrome (NMS), tardive dyskinesia (TD), an enlarged prostate gland, seizures, trouble urinating, mental or mood problems (eg, depression), an adrenal gland tumor (pheochromocytoma), high blood prolactin levels, certain types of cancer (eg, breast, pancreas, pituitary, brain), or alcohol abuse. Tell your doctor if you are at risk of breast cancer, if you are regularly exposed to extreme heat or certain insecticides (organophosphorus insecticides), or if you drink alcohol or are in alcohol withdrawal. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have certain types of brain damage, severe drowsiness, blood problems, liver damage, or decreased bone marrow function. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have recently taken large amounts of alcohol or medicines that may cause drowsiness, such as barbiturates (eg, phenobarbital) or narcotic pain medicines (eg, codeine). Use of this medicine in CHILDREN under age 12 is not recommended. Discuss with your doctor the risks and benefits of giving this medicine to your child. Contact your doctor or pharmacist if you have any questions about taking this medicine.
How to Use This Medicine:Follow the directions for using this medicine provided by your doctor. This medicine may be taken on an empty stomach or with food. If stomach upset occurs, take with food to reduce stomach irritation. IF YOU STOP TAKING THIS MEDICINE SUDDENLY and you have been taking it regularly or in high doses, you may have WITHDRAWAL symptoms, including nausea, vomiting, dizziness, stomach upset, and tremors. DO NOT EXCEED THE RECOMMENDED DOSE without checking with your doctor. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Do not store in the bathroom. KEEP THIS MEDICINE out of the reach of children and away from pets. IF YOU MISS A DOSE OF THIS MEDICINE and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Cautions:DO NOT TAKE THIS MEDICINE if you are allergic to any ingredient in this medicine or to other phenothiazines (eg, chlorpromazine). BEFORE USING THIS MEDICINE, tell your doctor if you have developed severe side effects (eg, blood problems, yellowing of the skin or eyes) while taking another phenothiazine. Lab tests may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you use this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. This medicine may cause drowsiness, dizziness, or blurred vision. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, along with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. THIS MEDICINE MAY CAUSE DIZZINESS, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. DO NOT DRINK ALCOHOL while you are using this medicine. Check with your doctor before you use medicines that may cause drowsiness while you are using this medicine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. DO NOT BECOME OVERHEATED in hot weather or during exercise or other activities because heat stroke may occur. THIS MEDICINE MAY CAUSE increased sensitivity to the sun. Avoid exposure to the sun or sunlamps until you know how you react to this medicine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. THIS MEDICINE MAY LOWER YOUR RESISTANCE TO INFECTION. Prevent infection by avoiding contact with people with colds or other infections. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of this medicine. FOR WOMEN: THIS MEDICINE MAY CAUSE THE RESULTS OF SOME PREGNANCY TESTS TO BE WRONG. IF YOU BECOME PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. Using this medicine during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. THIS MEDICINE IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. DIABETES PATIENTS: This medicine may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
Possible Side Effects:SIDE EFFECTS that may occur while taking this medicine include constipation, diarrhea, dizziness, drowsiness, dry mouth, enlarged pupils, jitteriness, headache, loss of appetite, nausea, stuffy nose, or vomiting. If they continue or are bothersome, check with your doctor. SOME PATIENTS WHO TAKE THIS MEDICINE may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take this medicine in higher doses or for a long time. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking this medicine. NEUROLEPTIC MALIGNANT SYNDROME (NMS) is a possibly fatal syndrome that can be caused by this medicine. Contact your doctor at once if you experience fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; or sweating. THIS MEDICINE MAY INCREASE THE AMOUNT OF A CERTAIN HORMONE (PROLACTIN) in your blood. Contact your doctor right away if you experience enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. CONTACT YOUR DOCTOR IMMEDIATELY if you experience chest pain; confusion; decreased coordination; drooling; fainting; fast, slow, or irregular heartbeat; mask-like face; muscle spasms of the face, neck, or back; muscle weakness; new or worsening mental or mood problems; numbness of an arm or leg; prolonged or painful erection; restlessness; seizures; severe or persistent constipation; severe or persistent dizziness, drowsiness, or headache; shuffling walk; sleeplessness; sudden shortness of breath or vomiting; swelling of the hands, ankles, or feet; symptoms of infection (eg, fever, chills, sore throat); symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, stomach pain, or loss of appetite); tremor; trouble urinating; twisting or twitching movements; uncontrolled muscle movements (eg, twitching of the face or tongue; loss of balance; uncontrolled movements of arms or legs; trouble speaking, breathing, or swallowing); unusual bruising or bleeding; unusual eye movements or inability to move eyes; unusual or excessive sweating; unusual tiredness or weakness; unusually pale skin; or vision changes (eg, blurred vision). AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness; or wheezing. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Overdose:IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include agitation; coma; confusion; difficulty breathing; fainting; fast, slow, or irregular heartbeat; loss of consciousness; muscle spasms or uncontrolled muscle movements; restlessness; seizures; severe constipation or stomach pain; severe drowsiness or dizziness; tremors; or trouble urinating.
Additional Information:DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF YOU WILL BE USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, be sure to obtain necessary refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.
Copyright 2014 Wolters Kluwer Health, Inc.