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Drug Information For:
VENLAFAXINE ER 225MG TABLETS
Ingredient Name:VENLAFAXINE (VEN-la-fax-een)
Drug Manufacturer:UPSTATE PHARMA, LLC
Common Uses:This medicine is a serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat depression, generalized or social anxiety disorder, or panic disorder. It may also be used for other conditions as determined by your doctor.
Before Using This Medicine:WARNING: ANTIDEPRESSANTS MAY INCREASE THE RISK OF SUICIDAL THOUGHTS OR ACTIONS in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using this medicine outweigh the risks. Family and caregivers must closely watch patients who take this medicine. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor. THIS MEDICINE IS NOT APPROVED FOR USE IN CHILDREN. Talk with the doctor. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking or have taken linezolid, a monoamine oxidase inhibitor (MAOI) (eg, phenelzine, selegiline), or St. John's wort within the last 14 days. DO NOT TAKE THIS MEDICINE if you are also taking a fenfluramine derivative (eg, dexfenfluramine), nefazodone, sibutramine, or tryptophan. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking anticoagulants (eg, warfarin), aripiprazole, aspirin, azole antifungals (eg, ketoconazole), bupropion, buspirone, cimetidine, clozapine, cyproheptadine, certain diet medicines (eg, phentermine, lorcaserin), diuretics (eg, furosemide, hydrochlorothiazide), fentanyl, haloperidol, lithium, meperidine, metoclopramide, metoprolol, nonsteroidal anti-inflammatory agents (NSAIDs) (eg, ibuprofen), phenothiazines (eg, chlorpromazine, thioridazine), risperidone, serotonin specific reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin and norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), 5-HT1 receptor agonists (eg, sumatriptan), terbinafine, tramadol, trazodone, tricyclic antidepressants (eg, amitriptyline), or a medicine that contains methylene blue. DO NOT START OR STOP any medicine without doctor or pharmacist approval. TELL YOUR DOCTOR if you will be having electroconvulsive therapy (ECT) or if you drink alcohol. Inform your doctor of any other medical conditions, including dehydration, low blood sodium levels, allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of seizures, heart problems (eg, heart failure, irregular heartbeat), abnormal ECG, recent heart attack, high blood pressure, high cholesterol, an overactive thyroid, liver or kidney problems, lung problems, stomach or bowel bleeding, blood or bleeding problems, diabetes, increased eye pressure (eg, glaucoma), nervous system problems, or metabolism problems. Tell your doctor if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
How to Use This Medicine:Follow the directions for taking this medicine provided by your doctor. This medicine comes with a MEDICATION GUIDE approved by the U.S. Food and Drug Administration. Read it carefully each time you refill this medicine. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. Take this medicine by mouth with food. Take this medicine with a full glass of water (8 oz/240 mL). SWALLOW THIS MEDICINE WHOLE. Do not break, crush, or chew before swallowing. DO NOT SUDDENLY STOP TAKING THIS MEDICINE without first checking with your doctor. You may have an increased risk of side effects (eg, mental or mood changes, numbness or tingling of the skin, dizziness, confusion, headache, increased sweating, diarrhea, nausea, vomiting, trouble sleeping, unusual tiredness). If you need to stop this medicine, your doctor may need to gradually lower your dose. DO NOT EXCEED THE RECOMMENDED DOSE or take this medicine for longer than prescribed without checking with your doctor. STORE THIS MEDICINE at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. KEEP THIS MEDICINE out of the reach of children and away from pets. This medicine works best if it is taken at the same time each day. Continue to take this medicine even if you feel well. Do not miss any doses. If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Cautions:DO NOT TAKE THIS MEDICINE if you are allergic to any ingredient in this medicine. Laboratory and/or medical tests may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LAB APPOINTMENTS. THIS MEDICINE MAY AFFECT certain lab test results. CHILDREN, TEENAGERS, AND ADULTS WHO TAKE THIS MEDICINE MAY BE AT INCREASED RISK FOR SUICIDAL THOUGHTS OR ACTIONS. Watch all patients who take this medicine closely, especially at the start of treatment with this medicine and whenever a change in dose is made. CONTACT THE DOCTOR AT ONCE if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. CONTACT YOUR DOCTOR AT ONCE if any signs of suicidal thoughts or actions occur. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, emergency care, or surgery, tell the doctor or dentist that you are using this medicine. This medicine may cause drowsiness, dizziness, blurred vision. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. DO NOT DRINK ALCOHOL while you are using this medicine. Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using this medicine. Ask your pharmacist if you have questions about which medicines may cause drowsiness. SEROTONIN SYNDROME and NEUROLEPTIC MALIGNANT SYNDROME (NMS) are possibly fatal syndromes that can be caused by this medicine. Your risk may be greater if you take this medicine with certain other medicines (eg, "triptans", MAOIs, antipsychotics). Symptoms may include blood pressure changes; agitation; confusion; hallucinations; other mental or mood changes; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; rigid muscles; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms. IF YOUR DOCTOR TELLS YOU TO STOP TAKING THIS MEDICINE, you will need to wait for a period of time before beginning to take certain other medicines (including MAOIs, nefazodone). Ask your doctor when you should start to take your new medicines after you have stopped taking this medicine. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY; they may be more sensitive to the effects of the medicine. This medicine may cause weight and growth changes. CHILDREN and teenagers may need regular weight and growth checks while they take this medicine. FOR WOMEN: This medicine may cause harm to the fetus if it is used during the last 3 months of pregnancy. IF YOU BECOME PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine.
Possible Side Effects:SIDE EFFECTS that may occur while taking this medicine include abnormal dreams, constipation, decreased sexual desire or ability, diarrhea, dizziness, drowsiness, dry mouth, headache, increased sweating, loss of appetite, nausea, nervousness, tiredness, trouble sleeping, vomiting, weakness, weight loss, or yawning. If they continue or are bothersome, check with your doctor. THIS MEDICINE MAY RARELY CAUSE a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. CONTACT YOUR DOCTOR IMMEDIATELY if you experience black, tarry, or bloody stools; blurred vision or other vision problems; chest pain or discomfort; confusion; decreased coordination; decreased urination; fainting; fast or irregular heartbeat; fever, chills, or persistent cough or sore throat; hallucinations; memory problems; new or worsening mental, mood, or behavior changes (eg, aggressiveness, agitation, anxiety, depression, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); persistent trouble sleeping; ringing in the ears; red, swollen, blistered, or peeling skin; seizures; severe stomach pain; severe or persistent headache or dizziness; shortness of breath; significant weight loss; suicidal thoughts or attempts; tremor; trouble concentrating; unsteadiness; unusual bruising or bleeding; or unusual weakness. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; or swelling of the mouth, face, lips, or tongue. If you notice any unusual effects, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Overdose:If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms may include coma; dilated pupils; fainting; fast, slow, or irregular heartbeat; muscle pain or weakness; new or worsening mental or mood problems; seizures; severe or persistent dizziness, drowsiness, or vomiting; trouble breathing; yellowing of the eyes or skin.
Additional Information:If your symptoms do not improve or if they become worse, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.
Copyright 2014 Wolters Kluwer Health, Inc.