MORPHINE SULFATE 30MG ER TABS (12H)   Enlarge image

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Drug Information For:


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Common Uses:

This medicine is a narcotic (opioid) pain medicine used to manage severe pain. This medicine is only for use when continuous (around-the-clock) treatment is needed for a long of time. It is also only for use when other pain treatments do not treat your pain well enough or you cannot take them. It is NOT for use right after surgery if you have not already been using narcotic pain medicines, if you need only occasional or "as-needed" relief, or if the pain is mild or is not expected to last for a long time. CERTAIN STRENGTHS OF THIS MEDICINE should only be used by patients who have already been taking other narcotic pain medicine on a regular schedule and are tolerant to its effects. The use of these strengths by people who are not used to taking narcotic pain medicine may cause severe and sometimes fatal breathing problems.

Before Using This Medicine:

WARNING: THIS MEDICINE IS A NARCOTIC PAIN MEDICINE that may become habit-forming. Misuse or abuse can lead to overdose and death. Do not take more than the recommended dose, take for longer than prescribed, or take more often than prescribed without checking with your doctor. THIS MEDICINE MAY CAUSE SEVERE AND SOMETIMES FATAL BREATHING PROBLEMS. The risk may be greater when you start this drug or with any dose increase. Contact your doctor right away if you experience slow, shallow, or difficult breathing. Be sure to swallow this medicine whole. Do NOT break, crush, cut, dissolve, or chew this medicine before swallowing it. Do NOT inject or snort this medicine. Doing any of these things could result in very serious side effects, including severe trouble breathing and death from overdose. ACCIDENTAL SWALLOWING OF EVEN ONE DOSE OF THIS MEDICINE may be fatal, especially in children. Keep this medicine out of the reach of children. Seek emergency medical care right away if another person swallows this medicine. LONG-TERM use during pregnancy may cause dependence in the unborn baby. This can lead to withdrawal in the newborn, which can be life-threatening. Discuss any questions or concerns with your doctor. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking buprenorphine, a mixed agonist/antagonist pain medicine (eg, butorphanol, nalbuphine, pentazocine), sodium oxybate (GHB), or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), or if you have taken an MAOI within the past 14 days. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking anticholinergics (eg, scopolamine, oxybutynin), cimetidine, diuretics (eg, furosemide, hydrochlorothiazide), muscle relaxants (eg, cyclobenzaprine), naltrexone, other narcotic pain medicines (eg, hydrocodone, oxycodone), phenothiazines (eg, chlorpromazine), quinidine, or rifamycins (eg, rifampin). TELL YOUR DOCTOR if you have never taken a narcotic pain medicine before. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of chronic obstructive pulmonary disease (COPD) or other lung or breathing problems (eg, asthma, bronchitis, emphysema), sleep apnea, curvature of the spine (scoliosis), a certain heart problem (cor pulmonale), high levels of carbon dioxide in the blood (hypercapnia or hypercarbia), low levels of oxygen in the blood (hypoxia), stomach or bowel problems (eg, blockage, inflammation), liver or kidney problems, gallbladder problems, pancreas problems (eg, pancreatitis), thyroid problems, an enlarged prostate, urinary blockage or trouble urinating, seizures (eg, epilepsy), suicidalthoughts or attempts, allergies, pregnancy, or breast-feeding. TELL YOUR DOCTOR if you have low blood pressure, dehydration, low blood volume, constipation, stomach pain, poor health, trouble swallowing, severe drowsiness, increased pressure in the brain, a recent head injury, or growths in the brain (eg, tumors, lesions). TELL YOUR DOCTOR if you are very overweight, have recently had or will be having surgery (eg, stomach or bowel surgery), or drink alcohol or have symptoms of alcohol withdrawal. TELL YOUR DOCTOR if you or a member of your family has a history of mental or mood problems (eg, depression), or alcohol or other substance abuse or dependence. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have narrowing of the stomach or bowels; known or suspected stomach or bowel blockage (eg, paralytic ileus); or slow, shallow, or difficult breathing. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have severe lung problems (eg, severe asthma) or you are having an asthma attack. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. This medicine has a MEDICATION GUIDE approved by the U.S. Food and Drug Administration. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. TAKE THIS MEDICINE BY MOUTH with or without food. If stomach upset occurs, take with food to reduce stomach irritation. This medicine must only be taken by mouth. Do not inject or snort this medicine. SWALLOW THIS MEDICINE WHOLE. Do not break, cut, crush, chew, or dissolve this medicine before swallowing. If you cannot swallow this medicine whole, tell your doctor. DO NOT SUDDENLY STOP TAKING THIS MEDICINE. You may have an increased risk of withdrawal symptoms, including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping. If you need to stop this medicine, your doctor will gradually lower your dose. STORE THIS MEDICINE at room temperature at 77 degrees F (25 degrees C), away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store in the bathroom. KEEP THIS MEDICINE out of the reach of children and away from pets. This medicine works best if it is taken at the same time(s) each day. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible then take your next dose as directed by your doctor. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do NOT take 2 doses at once. Do not take more than your prescribed dose in 24 hours.


DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or if you are allergic to any ingredient in this product. CHECK WITH YOUR DOCTOR BEFORE TAKING THIS MEDICINE if you have had an allergic reaction to any other narcotic pain medicine (eg, codeine, hydromorphone). WHEN USED FOR LONG PERIODS OF TIME OR AT HIGH DOSES, this medicine may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as tolerance. Talk with your doctor if this medicine stops working well. DO NOT EXCEED THE RECOMMENDED DOSE, take for longer than prescribed, or take more often than prescribed without checking with your doctor. SOME PEOPLE WHO USE THIS MEDICINE FOR A LONG TIME may develop a need to continue taking it. People who take high doses are also at risk. This is known as dependence or addiction. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, emergency care, or surgery, tell the doctor or dentist that you are using this medicine. THIS MEDICINE MAY CAUSE DIZZINESS, drowsiness, fainting, or lightheadedness. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. DO NOT DRINK ALCOHOL or take medicines (prescription or nonprescription) that have alcohol in them while you are taking this medicine. Check with your pharmacist if you have questions about whether any of your medicines contain alcohol. CHECK WITH YOUR DOCTOR BEFORE YOU USE MEDICINES THAT MAY CAUSE DROWSINESS (eg, sleep aids, muscle relaxers) while you are taking this medicine; the risk of severe drowsiness or breathing problems may be increased. Ask your pharmacist if you have questions about which medicines may increase the risk of these effects. IF YOUR PAIN CONTINUES OR BECOMES WORSE, or if you have side effects that concern you, contact your doctor. SEEK EMERGENCY MEDICAL CARE RIGHT AWAY if another person swallows this medicine. Accidental swallowing of this medicine may be fatal, especially in children. YOU MAY NOTICE THE TABLET SHELL IN YOUR STOOL after taking this medicine. This is normal and not a cause for concern. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine, especially breathing problems. FOR WOMEN: IF YOU THINK YOU MAY BE PREGNANT, discuss with your doctor the benefits and risks of usingthis medicine during pregnancy. Long-term use of this medicine during pregnancy may cause dependence in the fetus or newborn. Discuss any questions or concerns with your doctor. THIS MEDICINE IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while using this medicine include dizziness, drowsiness, headache, mild stomach pain, nausea, sweating, tiredness, or vomiting. If they continue or are bothersome, check with your doctor. THIS MEDICINE MAY CAUSE CONSTIPATION. Talk with your doctor or pharmacist about using a stool softener or laxative to prevent constipation. It is also important to maintain a diet adequate in fiber, drink plenty of water, and exercise to prevent constipation. If you become constipated while taking this medicine, talk with your doctor or pharmacist. CONTACT YOUR DOCTOR IMMEDIATELY if you experience abnormal sighing; burning, numbness, or tingling; chest pain; confusion; fainting; fast, slow, or irregular heartbeat; hallucinations; memory problems; mental or mood changes (eg, agitation, depression); seizures; severe or persistent constipation, stomach pain, or vomiting; severe or persistent dizziness, drowsiness, headache, or lightheadedness; shortness of breath; slow, difficult, or shallow breathing; swelling of the hands, ankles, or feet; tremor; trouble talking, thinking, or walking; trouble urinating; unusual tiredness or weakness; or vision changes (eg, blurred vision). AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; or swelling of the mouth, face, lips, throat, or tongue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include bluish skin or nails; cold and clammy skin; coma; difficult, shallow, or slow breathing; fainting; limp muscles; pinpoint or enlarged pupils; severe drowsiness, dizziness, or lightheadedness; shortness of breath; or slow or irregular heartbeat.

Additional Information:

DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out. IF THIS MEDICINE IS NO LONGER NEEDED, dispose of it as soon as possible. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.