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Drug Information For:


Ingredient Name:

CYCLOSPORINE (SYE-kloe-spor-een)

Drug Manufacturer:


Common Uses:

This medicine is an immunosuppressant used to prevent the rejection of organ transplants (kidney, liver, and heart). It is used in combination with adrenal corticosteroids. It may also be used to treat chronic rejection in patients previously treated with other immunosuppressive agents. It may also be used to treat other conditions as determined by your doctor.

Before Using This Medicine:

WARNING: This medicine should be used with adrenal corticosteroids (eg, hydrocortisone). It should not be used with other medicines that suppress the immune system. Suppressing the immune system may increase the risk of developing an infection or a certain type of cancer (lymphoma). THIS MEDICINE CANNOT BE SWITCHED with other forms of cyclosporine (eg, Neoral) without your doctor's approval. IF YOU ARE TAKING THIS MEDICINE FOR A LONG PERIOD OF TIME, lab tests should be performed to monitor your progress or to check for side effects. This is especially important for liver transplant patients. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking aliskiren, bosentan, disulfiram, dronedarone, enzalutamide, lovastatin, metronidazole, mifepristone, orlistat, pitavastatin, a potassium-sparing diuretic (eg, spironolactone), simvastatin, or another medicine used to suppress the immune system (eg, azathioprine, sirolimus). DO NOT TAKE THIS MEDICINE if you have taken or will be taking tacrolimus within 24 hours before or after using this medicine. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking other prescription or nonprescription medicines (eg, used for infections, inflammation, allergic reactions, asthma, aches and pains, high blood pressure, cancer, gout, diabetes, heartburn or reflux, high cholesterol, irregular heartbeat or other heart problems, birth control, Parkinson disease, stomach or bowel problems, endometriosis, HIV, seizures, blood thinning, weight loss, arthritis, psoriasis, depression or other mental or mood problems, sleep, fibrocystic breast disease, hepatitis C, high blood prolactin levels, immune system suppression, pulmonary arterial hypertension / PAH), multivitamin products, or herbal or dietary supplements (eg, St. John's wort). Tell your doctor if you are taking medicines that may harm the kidney (eg, aminoglycoside antibiotics, such as gentamicin; amphotericin B; nonsteroidal anti-inflammatory drugs / NSAIDs, such as ibuprofen; tacrolimus; vancomycin) or the liver (eg, acetaminophen, methotrexate, ketoconazole, isoniazid, certain medicines for HIV infection). Ask your doctor or pharmacist if you are unsure if any of your medicines might harm the kidney or liver, or might interact with this medicine. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including liver, kidney, brain, or nerve problems; gout or high blood uric acid levels; low blood magnesium or cholesterol levels; high blood pressure; cancer; an infection; a weakened immune system; problems absorbing food ormedicine; high blood potassium levels; allergies; pregnancy; or breast-feeding. Tell your doctor if you have recently had or will be having a vaccine, if your diet contains a lot of potassium, or if you have a history of seizures. Tell your doctor if you are having phototherapy for psoriasis, or are having radiation treatment. USE OF THIS MEDICINE IS NOT RECOMMENDED if you are having radiation therapy, including PUVA or UVB therapy, for psoriasis. Contact your doctor or pharmacist if you have any questions about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. This medicine is usually administered as an injection at a hospital or clinic. This medicine is sometimes used at home as an injection. If you are using this medicine at home, a healthcare professional will provide detailed instructions for its appropriate use. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. DO NOT EAT GRAPEFRUIT OR DRINK GRAPEFRUIT JUICE while you are using this medicine. STORE THIS MEDICINE as directed on the prescription label. Protect from heat, moisture, and light. KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.


DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or if you are allergic to any ingredient in this product or to Cremophor EL. DO NOT SWITCH to another doseform or change brands of this medicine without talking to your doctor. Products made by other companies may not work as well for you. LABORATORY AND/OR MEDICAL TESTS, including kidney and liver function; cyclosporine levels; and blood pressure, lipids, and electrolytes, may be performed to monitor your progress or to check for side effects. Keep all doctor and laboratory appointments while you are taking this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, emergency care, or surgery, tell the doctor or dentist that you are taking this medicine. THIS MEDICINE MAY CAUSE DIZZINESS. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine. Using this medicine alone, along with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. THIS MEDICINE MAY INCREASE YOUR RISK OF SKIN CANCER. Avoid the sun, sunlamps, or tanning booths until you know how you react to this medicine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. It may also increase your risk of developing other forms of cancer (eg, lymphoma). Discuss any questions or concerns with your doctor. THIS MEDICINE MAY REDUCE THE NUMBER OF BLOOD CELLS THAT ARE NEEDED FOR CLOTTING. To prevent bleeding, avoid situations where bruising or injury may occur. THIS MEDICINE MAY LOWER YOUR RESISTANCE TO INFECTION. This may increase the risk of serious and sometimes fatal infections. Prevent infection by avoiding contact with people with colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first. DO NOT USE A SALT SUBSTITUTE or potassium supplement without checking with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. DO NOT RECEIVE A LIVE VACCINE (eg, measles, mumps) while you are taking this medicine. Talk with your doctor before you receive any vaccine. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of this medicine. FOR WOMEN: THIS MEDICINE HAS BEEN SHOWN TO CAUSE HARM to the human fetus. IF YOU BECOME PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine. DIABETES PATIENTS: This medicine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while taking this medicine include acne; dizziness; flushing; headache; increased hair growth; mild diarrhea; nausea; runny nose; sleeplessness; stomach discomfort; or vomiting. If they continue or are bothersome, check with your doctor. SOME PATIENTS TREATED WITH THIS MEDICINE have developed severe and sometimes fatal infections, such as progressive multifocal leukoencephalopathy (PML) or severe kidney problems associated with BK virus infection. In kidney transplant patients, BK virus infection may cause loss of the transplanted kidney. Tell your doctor right away if you notice symptoms of PML (eg, confusion or disorientation; you do not care about things that you usually care about; changes in thinking, strength, or vision; one-sided weakness; trouble walking or talking; loss of balance or coordination) or kidney problems (eg, change in the amount of urine produced, difficult or painful urination, blood in the urine). CONTACT YOUR DOCTOR IMMEDIATELY if you experience black, tarry stool; burning, numbness, or tingling; change in the appearance of a mole; chest, jaw, or arm pain; confusion; decreased coordination; fast or irregular heartbeat; gum disease or overgrowth; mental or mood changes (eg, depression); mouth sores or swelling; muscle aches, cramps, pain, or weakness; ringing in the ears or hearing loss; seizures; severe or persistent diarrhea; severe or persistent headache or dizziness; shortness of breath; stomach pain; sudden unusual sweating; symptoms of infection (eg, fever, chills, sore throat, severe or persistent cough, increased or painful urination, warm or painful skin); symptoms of liver problems (eg, dark urine; pale stools; severe or persistent nausea, vomiting, or loss of appetite); tremors; unusual bleeding or bruising; unusual lumps; unusual swelling; unusual thickening or growth on the skin; unusual tiredness or weakness; vision changes (eg, blindness); vomit that looks like coffee grounds; wheezing; or yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; or swelling of the mouth, face, lips, or tongue. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately. Symptoms of overdose may include drowsiness, fast or irregular heartbeat, headache, symptoms of kidney problems (eg, change in the amount of urine produced), or vomiting.

Additional Information:

DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.