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Drug Information For:


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Common Uses:

This medicine is a fluoroquinolone antibiotic used for treating bacterial infections. It may also be used to prevent or slow anthrax after exposure.

Before Using This Medicine:

WARNING: This medicine is associated with an increased risk of tendon problems. These include pain, swelling, inflammation, and possible breakage of tendons. The risk of tendon problems is greater in patients who are over 60 years old, patients who take corticosteroids (eg, prednisone), and in those who have received kidney, heart, or lung transplants. The Achilles tendon in the back of the foot/ankle is most often affected. However, problems may also occur in other tendons (eg, in the shoulder, arm, hand). Problems may occur while you take this medicine or up to several months after you stop taking it. SIGNS OF TENDON PROBLEMS may include pain, soreness, redness, or swelling of a tendon or joint; bruising right after an injury in a tendon area; hearing or feeling a snap or pop in a joint or tendon area; or inability to move or bear weight on a joint or tendon area. Tell your doctor right away if you experience any of these symptoms while you take this medicine or within several months after you stop taking it. THIS MEDICINE MAY WORSEN muscle weakness and breathing problems in patients with myasthenia gravis. Do not take this medicine if you have a history of myasthenia gravis. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking agomelatine, lomitapide, pirfenidone, pomalidomide, tizanidine, or have recently received a live oral typhoid vaccination. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking antiarrhythmics (eg, quinidine, amiodarone), anticoagulants (eg, warfarin), antipsychotics (eg, clozapine, olanzapine), corticosteroids (eg, prednisone), cyclosporine, diuretics (eg, furosemide, hydrochlorothiazide), duloxetine, hydantoins (eg, phenytoin), macrolide antibiotics (eg, clarithromycin, methadone, methotrexate, metoclopramide, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), probenecid, ropinirole, sildenafil, sulfonylureas (eg, glyburide), theophylline, tricyclic antidepressants (eg, amitriptyline), or xanthines (eg, pentoxifylline). TELL YOUR DOCTOR if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a stomach infection, liver problems, brain or nervous system problems, increased pressure in the brain, Alzheimer disease, brain blood vessel problems, muscle problems (eg, myasthenia gravis),allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of stroke; severe or persistent diarrhea; skin sensitivity to the sun; low blood potassium or magnesium levels; heart problems; irregular heartbeat (eg, QT prolongation); joint or tendon problems; rheumatoid arthritis; kidney problems or decreased kidney function; heart, kidney, or lung transplant; or seizures. Tell your doctor if you have a family member with a history of irregular heartbeat. Tell your doctor if you participate in strenuous physical work or exercise. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of myasthenia gravis. Contact your doctor or pharmacist if you have any questions or concerns about using this medicine.

How to Use This Medicine:

Follow the directions for taking this medicine provided by your doctor. This medicine comes with a MEDICATION GUIDE approved by the U.S. Food and Drug Administration. Read it carefully each time you refill this medicine. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. Take this medicine by mouth with or without food. The preferred dosing time is 2 hours after a meal. SHAKE WELL before each use. USE A MEASURING DEVICE marked for medicine dosing. Ask your pharmacist for help if you are unsure how to measure your dose. Take this medicine with a full glass of water (8 oz/240 mL). DRINKING EXTRA FLUIDS while you are taking this medicine is recommended. Check with your doctor for instructions. IF YOU ALSO TAKE ANY PRODUCTS CONTAINING magnesium, aluminum, calcium, iron, or zinc (eg, antacids, quinapril, vitamins/minerals); didanosine; sucralfate; or bismuth subsalicylate, do not take them within 6 hours before or 2 hours after taking this medicine. IF YOU ALSO TAKE SEVELAMER, do not take it within 4 hours before or after taking this medicine. Check with your doctor if you have questions. AVOID TAKING THIS MEDICINE with milk or milk products (eg, calcium-enriched juice, yogurt) by themselves. However, taking this medicine as part of a full meal that contains milk or milk products is permitted. STORE THIS MEDICINE below 86 degrees F (30 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. THROW AWAY ANY UNUSED MEDICINE AFTER 14 DAYS. KEEP THIS MEDICINE out of the reach of children and away from pets. This medicine works best if it is taken at the same time each day. TO CLEAR UP YOUR INFECTION COMPLETELY, take this medicine for the full course of treatment. Keep taking it even if you feel better in a few days. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.


DO NOT USE THIS MEDICINE IF you are allergic to any ingredient in this medicine or to any other fluoroquinolone (eg, levofloxacin). THIS MEDICINE MAY CAUSE DROWSINESS, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use this medicine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. THIS MEDICINE ONLY WORKS AGAINST BACTERIA; it does not treat viral infections (eg, the common cold). BEFORE USING THIS MEDICINE, tell your doctor if you take a medicine that contains caffeine or if you consume large amounts of food or drink that contain caffeine (eg, coffee, tea, cocoa, cola, chocolate). TELL YOUR DOCTOR RIGHT AWAY IF YOU EXPERIENCE PAIN OR SWELLING OF A TENDON or weakness or loss of use of a joint area. Rest the area and avoid exercise until further instruction from your doctor. THIS MEDICINE MAY CAUSE YOU TO BECOME SUNBURNED more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to this medicine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. MILD DIARRHEA IS COMMON WITH ANTIBIOTIC USE. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINES, either prescription or over-the-counter, check with your doctor or pharmacist. Use this medicine with caution in the ELDERLY; they may be more sensitive to its effects (eg, tendon problems), especially if they take corticosteroids (eg, prednisone). They may also be more sensitive to other effects (eg, irregular heartbeat). This medicine should be used with extreme caution in CHILDREN younger than 18 years old; they may be more sensitive to its effects, especially joint and tendon problems. FOR WOMEN: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using this medicine while you are pregnant. This medicine is found in breast milk. Do not breast-feed while taking this medicine. DIABETES PATIENTS - This medicine may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while taking this medicine include diarrhea, dizziness, headache, nausea, or vomiting. If they continue or are bothersome, check with your doctor. THIS MEDICINE MAY WORSEN muscle weakness and breathing problems in patients with myasthenia gravis. Do not take this medicine if you have a history of myasthenia gravis. NERVE PROBLEMS in the arms, hands, legs, or feet can happen in people taking this medicine. These nerve problems can happen soon after this medicine is started and may be permanent. Call your doctor right away if you have symptoms or nerve problems (eg, not able to handle heat or cold; decreased sensation of touch; unusual burning, numbness, tingling, pain, or weakness of the arms, hands, legs, or feet). CONTACT YOUR DOCTOR IMMEDIATELY if you experience bloody or tarry stools; change in the amount of urine produced; chest pain; fainting; fast or irregular heartbeat; fever, chills, or unusual cough; hallucinations; inability to move or bear weight on a joint or tendon area; moderate to severe sunburn; mood or mental changes (eg, new or worsening anxiety, agitation, confusion, depression, nervousness, nightmares, paranoia, restlessness, sleeplessness); muscle pain or weakness; pain, soreness, redness, swelling, weakness, or bruising of a tendon or joint area; persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea; severe or persistent dizziness; shortness of breath or trouble breathing; stomach cramps/pain; suicidal thoughts or actions; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, unusual stomach pain, yellowing of the skin or eyes); tremors; unusual bruising or bleeding; unusual fatigue; vaginal yeast infection; or vision changes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing or swallowing; tightness in the chest or throat; or swelling of the mouth, face, lips, or tongue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If overdose is suspected, contact your local poison control center or emergency room immediately.

Additional Information:

If your symptoms do not improve within a few days or if they become worse, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions, or later for other infections. A different medicine may be needed in those cases. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.