DEPO-PROVERA *400MG/ML* 2.5ML VIAL   Enlarge image

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Drug Information For:


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Common Uses:

This medicine is a progestin hormone used to treat certain cancers. It may also be used to treat other conditions as determined by your doctor.

Before Using This Medicine:

Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking rifampin or aminoglutethimide. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of certain bone problems (metabolic bone disease), anorexia, chronic alcohol or tobacco use, seizure, migraine, asthma, heart problems (including heart failure or high blood pressure), kidney problems, mental or mood problems (eg, depression), diabetes or a family history of diabetes, irregular menstrual periods, lumps in your breast, bleeding from the nipples, abnormal mammogram, cancer, fibrocystic breast disease, family history of breast cancer, family history of osteoporosis, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have unexplained vaginal bleeding, or a history of breast cancer or genital cancer, stroke or bleeding in the brain, liver problems, blood clots (including clots in the leg or the lung), problems with blood vessels, or problems with blood vessels in your brain. USE OF THIS MEDICINE IS NOT RECOMMENDED if you are pregnant. This medicine should not be used to diagnose pregnancy. Use of this medicine in CHILDREN is not recommended. Discuss with your doctor the risks and benefits of giving this medicine to your child. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. This medicine may come with a patient information leaflet. Read it carefully. This medicine is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using this medicine at home, a healthcare professional will provide detailed instructions for its appropriate use. Ask any questions that you may have about this medicine or giving injections. If the medicine contains particles, is cloudy or discolored, or if the vial is cracked or damaged in any way, do not use it. STORE THIS MEDICINE as directed on the prescription label. KEEP THIS PRODUCT, as well as syringes and needles, out of the reach of children and away from pets. IF YOU MISS A DOSE OF THIS MEDICINE, contact your doctor as soon as possible.


DO NOT USE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. This medicine does not protect against HIV infection (AIDS) or other sexually transmitted diseases. Laboratory and/or medical tests, including bone density tests; blood pressure measurements; blood calcium; or breast, abdominal, or pelvic examinations, may be performed to monitor your progress or to check for side effects. You should have a physical examination regularly as directed by your doctor while you are using this medicine. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are using this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you are taking this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. This medicine may take time to wear off after your last dose. You may not be able to become pregnant for several months after stopping this medicine. Discuss any concerns with your doctor or pharmacist. This medicine may cause dizziness, drowsiness, lightheadedness, or vision changes. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. THIS MEDICINE MAY CAUSE dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths. USE OF THIS MEDICINE MAY CAUSE A DECREASE IN THE AMOUNT OF CALCIUM in your bones and increase your risk of osteoporosis or bone fracture. A decrease in bone calcium is of most concern if you have the following risk factors: adolescence, bone disease, anorexia nervosa (an eating disorder), a strong family history of osteoporosis, if you take certain medicines (eg, for epilepsy or steroids), or if you drink a lot of alcohol or smoke cigarettes often. When this medicine is stopped, the calcium in bones begins to come back. Your health care provider may recommend that you take calcium or vitamin D to help lower the amount of calcium lost from your bones. BEFORE YOU BEGIN TAKING ANY OTHER MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. FOR WOMEN: DO NOT USE THIS MEDICINE if you are pregnant. IF YOU SUSPECT THAT YOU COULD BE PREGNANT, contact your doctor immediately. THIS MEDICINE IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. IF YOU HAVE DIABETES, this medicine may affect your blood sugar. Check your blood sugar level closely and ask your doctor before adjustingthe dose of your diabetes medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while taking this medicine include changes in menstrual flow, including breakthrough bleeding, spotting, or missed periods; headache; weakness or tiredness; stomach pain or discomfort; nausea; trouble sleeping; dizziness; drowsiness; hot flashes; acne; nervousness; hair loss; decreased interest in sex; breast pain or tenderness. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience mental or mood changes (eg, depression); unusual vaginal discharge or irritation; or swelling of your hands, legs, ankles, or feet. IF YOU MISS A MENSTRUAL PERIOD and think that you may be pregnant, contact your doctor right away. CHECK WITH YOUR DOCTOR IMMEDIATELY if you experience breast lumps or nipple bleeding; dark urine; fast heartbeat; fever; pale stools; unusually heavy or continuous vaginal bleeding; seizures; sudden or severe headache; sudden or severe vomiting or dizziness; fainting; sudden loss of coordination; slurred speech; sudden loss of vision or changes in vision; weakness, numbness, or pain in the arms or legs; chest pain; sudden shortness of breath; coughing up blood; pain, swelling, or tenderness in the calf; severe stomach pain or tenderness; unusual weight gain or loss; yellowing of the eyes/skin; or pain, pus, or bleeding at the injection site. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If overdose is suspected, contact your local poison control center or emergency room immediately.

Additional Information:

FOLLOW YOUR DOCTOR'S INSTRUCTIONS for taking calcium and vitamin D while you are using this medicine. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2014 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.