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Drug Information For:


Ingredient Name:

ERYTHROMYCIN (eh-rith-roe-MYE-sin) and SULFISOXAZOLE (sul-fi-SOX-a-zole)

Drug Manufacturer:


Common Uses:

This medicine is a macrolide antibiotic and a sulfonamide combination used to treat infections.

Before Using This Medicine:

Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking certain antiarrhythmics (eg, amiodarone, dofetilide, dronedarone, procainamide, propafenone, quinidine, sotalol), asenapine, astemizole, cisapride, diltiazem, eletriptan, an ergot alkaloid (eg, dihydroergotamine, ergotamine), an HIV protease inhibitor (eg, ritonavir), certain imidazole antifungals (eg, itraconazole, ketoconazole, voriconazole), nilotinib, pimozide, a streptogramin (eg, quinupristin/dalfopristin), terfenadine, tetrabenazine, tolvaptan, or verapamil. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking other prescription and nonprescription medicines (eg, used for aches and pains, allergies, blood thinning, breathing problems, cancer, diabetes, erection problems, gout, hepatitis C infection, high blood calcium levels, high blood pressure, high cholesterol, HIV infection, inflammation, infections, irregular heartbeat or other heart problems, low blood sodium levels, migraine, mood or mental problems, nausea and vomiting, overactive bladder, Parkinson disease, prevention of organ transplant rejection, seizures, stomach problems, trouble sleeping), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort). Tell your doctor if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat or might interfere with this medicine. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including diarrhea, throat inflammation, allergies, pregnancy, or breast-feeding. Tell your doctor if you have a history of asthma, blood problems, glucose-6-phosphate dehydrogenase (G6PD) deficiency, kidney or liver problems, heart problems (eg, fast, slow, or irregular heartbeat), low blood potassium or magnesium levels, myasthenia gravis, or the blood disease porphyria. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have severe kidney problems, bladder blockage, anemia cause by folic acid deficiency, a very slow heartbeat, a certain type of irregular heartbeat (QT prolongation, long QT syndrome), or low blood potassium or magnesium levels. USE OF THIS MEDICINE IS NOT RECOMMENDED if you are pregnant and at term (38 to 42 weeks), or if you are breast-feeding a child younger than 2 months of age. Use of this medicine in CHILDREN under 2 months of age is not recommended. Discuss with your doctor the risks and benefits of giving thismedicine to your child. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. SHAKE WELL before taking a dose. IF THIS MEDICINE UPSETS YOUR STOMACH, take it with food. DRINKING EXTRA FLUIDS while you are taking this medicine is recommended. Check with your doctor or nurse for instructions. DO NOT EAT GRAPEFRUIT OR DRINK GRAPEFRUIT JUICE while you are using this medicine. STORE THIS MEDICINE in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Throw away any unused medicine after 14 days. KEEP THIS MEDICINE out of the reach of children and away from pets. This medicine works best if it is used at the same time(s) each day. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel better in a few days. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.


DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it, to any ingredient in this product, or to any other sulfonamide medicine (eg, sulfamethoxazole). Laboratory and/or medical tests, including liver function, kidney function, complete blood counts, and urinalysis, may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you use this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are taking this medicine. This medicine may cause dizziness. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, along with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. MILD DIARRHEA IS COMMON WITH ANTIBIOTIC USE. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. THIS MEDICINE ONLY WORKS AGAINST BACTERIA; it does not treat viral infections (eg, the common cold). BE SURE TO USE THIS MEDICINE FOR THE FULL COURSE OF TREATMENT. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. LONG-TERM OR REPEATED USE OF THIS MEDICINE may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. THIS MEDICINE MAY CAUSE increased sensitivity to the sun. Avoid exposure to the sun or sunlamps until you know how you react to this medicine. Use a sunscreen if you must be outside for a prolonged period. INFREQUENTLY, A SERIOUS STOMACH PROBLEM CALLED IHPS (infantile hypertrophic pyloric stenosis) has been reported in infants taking erythromycin. Contact your child's doctor right away if severe vomiting or irritability with feeding occurs. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of this medicine, especially irregular heartbeat (prolonged QT interval). FOR WOMEN: IF YOU BECOME PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. Do not take this medicine if you are pregnant and at term (38 to 42 weeks). THIS MEDICINE ISEXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking this medicine.

Possible Side Effects:

SIDE EFFECTS that may occur while taking this medicine include dizziness, headache, loss of appetite, mild diarrhea, nausea, stomach pain, or vomiting. If they continue or are bothersome, check with your doctor. RARELY, CERTAIN PATIENTS TAKING THIS MEDICINE have developed reversible hearing loss. This risk is greater if you have kidney problems or you take high doses of this medicine. Contact your doctor if you develop decreased hearing or hearing loss. CONTACT YOUR DOCTOR IMMEDIATELY if you experience bloody or dark urine; bloody stools; change in the amount of urine; fainting; fast or irregular heartbeat; fever, chills, or sore throat; mood or mental changes; numbness or tingling of the hands or feet; pale skin; red, swollen, blistered, or peeling skin; ringing in the ear; seizures; severe or persistent diarrhea, dizziness, or headache; severe stomach pain; stomach cramps; shortness of breath; sore mouth or tongue; symptoms of liver problems (eg, yellowing of the skin or eyes; pale stools; severe or persistent nausea, vomiting, or loss of appetite; dark urine); unusual bruising or bleeding; unusual weakness or fatigue; or vision changes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include blood in the urine; high fever; loss of consciousness; severe or persistent loss of appetite; severe nausea, vomiting, dizziness, drowsiness, or headache.

Additional Information:

DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.