NIASPAN 1000MG ER TABLETS   Enlarge image

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Drug Information For:


Ingredient Name:

NIACIN (NYE-a-sin)

Drug Manufacturer:


Common Uses:

This medicine is an antihyperlipidemic used to improve cholesterol levels and lower very high serum triglyceride levels. It is also used to reduce the risk for a second heart attack or slow or treat hardening of the arteries in certain patients with high cholesterol. This medicine is used in combination with diet. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Before Using This Medicine:

Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking anticoagulants (eg, warfarin), fibrates (eg, gemfibrozil, fenofibrate), HMG-CoA reductase inhibitors ("statins") (eg, lovastatin, simvastatin), calcium channel blockers (eg, amlodipine), alcohol, or nitrates (eg, isosorbide dinitrate) or other medicines for high blood pressure (eg, clonidine, prazosin). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including a history of bleeding problems, chest pain (angina), diabetes, gallbladder problems, glaucoma, gout, heart problems or a recent heart attack, kidney or liver problems, jaundice (yellowing of the skin or eyes), low blood pressure, low phosphate levels, muscle problems (eg, rhabdomyolysis), stomach problems (eg, peptic ulcers), thyroid problems, allergies, pregnancy, or breast-feeding. Tell your doctor if you consume large amounts of alcohol or if you will be having surgery. Tell your doctor if you take aspirin, or vitamins or supplements that contain niacin or nicotinamide. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have liver problems, unexplained abnormal liver function tests, a stomach ulcer, or a certain bleeding problem (arterial bleeding). Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

How to Use This Medicine:

Follow the directions for using this medicine provided by your doctor. An additional patient information leaflet is available with this medicine. Ask your doctor, nurse, or pharmacist any questions that you may have about this information. SWALLOW WHOLE. Do not break, crush, or chew before swallowing. TO MINIMIZE FLUSHING AND UPSET STOMACH, take this medicine at bedtime after a low-fat snack (eg, low-fat yogurt, banana, crackers with a glass of milk) unless your doctor directs otherwise. Do not take this medicine on an empty stomach. Do NOT take this medicine with alcohol, a hot drink, or spicy foods. Do NOT take bile acid sequestrants (eg, colestipol, cholestyramine) within 4 to 6 hours of taking this medicine. DO NOT SUBSTITUTE this medicine for any other type of niacin without talking with your doctor. Severe liver damage can occur. IF YOU STOP TAKING THIS MEDICINE for an extended period, contact your doctor before you start taking it again. Your dose may need to be adjusted. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly-closed container, away from heat, moisture, and light. KEEP THIS MEDICINE out of the reach of children and away from pets. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss several doses, contact your doctor.


DO NOT TAKE THIS MEDICINE if you are allergic to any ingredient in it. DO NOT EXCEED THE RECOMMENDED DOSE or take this medicine for longer than prescribed without checking with your doctor. Lab tests, including liver function tests, blood glucose, blood potassium, and serum creatine phosphokinase tests, may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. This medicine may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking this medicine. BEFORE YOU HAVE ANY MEDICAL OR DENTAL TREATMENTS, EMERGENCY CARE, OR SURGERY, tell the doctor or dentist that you are using this medicine. This medicine may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of these effects. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to this medicine. Using this medicine alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. THIS MEDICINE MAY REDUCE THE NUMBER OF BLOOD CELLS THAT ARE NEEDED FOR CLOTTING. To prevent bleeding, avoid situations where bruising or injury may occur. FOLLOW THE DIET AND EXERCISE PROGRAM given to you by your health care provider. FLUSHING OCCURS WITH THIS MEDICINE AND MAY LAST FOR SEVERAL HOURS. Take this medicine at bedtime so that flushing will occur during sleep, unless your doctor directs otherwise. If you are awakened by flushing at night, get up slowly, especially if you feel dizzy or faint or if you are taking blood pressure medicines. Taking aspirin 30 minutes before you take this medicine may lessen flushing. Talk with your doctor to see if you should take aspirin before you take this medicine or if flushing becomes bothersome. REPORT ANY UNEXPLAINED MUSCLE PAIN, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine, especially muscle problems. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. THIS MEDICINE IS EXCRETED in breast milk. DO NOT BREAST-FEED while taking this medicine. IF YOU HAVE DIABETES, this medicine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine. This medicine may cause false test results with some urine glucose tests. Check with your doctor beforeadjusting the dose of your diabetes medicine or changing your diet.

Possible Side Effects:

SIDE EFFECTS that may occur while taking this medicine include diarrhea; dizziness; headache; heartburn; increased cough, indigestion, or upset stomach; nausea; temporary skin redness, itching, tingling, or feelings of warmth (flushing); or vomiting. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience black, tarry, or bloody stools; changes in vision (eg, cloudy or blurred vision); decrease in urine or dark-colored urine; fainting; fast or irregular heartbeat; fever or chills; increased sweating; loss of appetite; muscle pain, tenderness, swelling, or weakness (with or without fever and fatigue); numbness or persistent tingling of the skin; pale stools; severe dizziness or headache; severe or persistent diarrhea, nausea, or vomiting; shortness of breath; stomach pain; swelling of the hands, legs, or feet; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; confusion; drowsiness; rapid breathing; fruit-like breath odor); unusual bruising or bleeding; unusual tiredness; vomit that looks like coffee grounds; or yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms may include flushing.

Additional Information:

DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out. Check with your pharmacist about how to dispose of unused medicine.

Copyright 2015 Wolters Kluwer Health, Inc.


- This information is not intended to substitute for professional medical advice. Be sure to contact your physician, pharmacist or other health care provider for more information about this medication. By searching these web site pages, you agree to our terms and conditions of use.