Do not use when nausea or vomiting are present unless directed by a doctor. Consult a doctor if you notice a sudden change in bowel habits that persist over 2 weeks. Rectal bleeding or failure to move bowels after use may indicate a serious condition. Discontinue use and consult a doctor. This product contains Cascara sagrada. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because Cascara sagrada may worsen these conditions and be harmful to your health. Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition. Freshness & safety sealed with printed outer shrinkwrap and printed inner seal. Do not use if either seal is broken or missing. Keep out of the reach of children.For relief of occasional constipation (irregularity). This product generally produces bowel movement in 6 to 12 hours.