Rinsing your nasal passages with only plain water will result in a severe burning sensation. When reusing the bottle, use lukewarm distilled, filtered or previously boiled water, properly mixed with NeilMed SINUS RINSE packets. Do not use tap or faucet water for dissolving the mixture unless it has been previously boiled and cooled down. Do not rinse if nasal passages are completely blocked or if you have an ear infection or blocked ears. If you have had recent ear or sinus surgery, contact your physician prior to irrigation. If you experience any pressure in the ears, stop irritation and get further directions from your physician. Keep out of reach of children. Read and retain the enclosed brochure, if provided, for instructions and other important information. Inside components of this unit are not for individual sale. Do not discard this printed box and any enclosed printed material. The inside final product may not have all the details you require for the ongoing use of the product. STORE IN A COOL & DRY PLACE.