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What are the side effects of SAM-e?


SAM-e is a compound your body makes from an amino acid called methionine, which is commonly found in food. Cells in the body use SAM-e to make cartilage and repair cell damage. SAM-e, as a dietary supplement, is marketed for its ability to promote "joint health" and "emotional well-being." The active ingredient in SAM-e is S-adenosylmethionine.

Potential SAM-e side effects

The reported side effects of SAM-e are mild, and occur infrequently. They include stomach upset, diarrhea, headaches, and nausea. If you are taking prescription medicines for depression, or if you have a bipolar disorder (also called manic depression), you should consult with your physician before using this product as its use may not be recommended.

Back to Ask a Pharmacist


Answers to questions regarding information about medications or health conditions are not for diagnostic or treatment purposes and are not conclusive as to the presence or absence of any health condition. Consult your physician for diagnosis and treatment of your medical condition. The information provided is not a substitute for medical advice. Advances in medicine may cause this information to become outdated, invalid or subject to debate. Professional opinions and interpretations of the scientific literature may vary. Walgreens' terms of use and general warranty disclaimer apply to all services provided. If you are in need of immediate medical attention, contact your physician, poison control center or emergency medical professional. If you need to speak with a pharmacist for non-emergency matters, contact your local Walgreens pharmacist or call a pharmacist toll-free at 1 (877) 250-5823.

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