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What are the side effects of nefazodone?


Nefazodone is an antidepressant drug used to treat depression. Most people tolerate nefazodone well without any side effects. Nefazodone works by boosting levels of serotonin and norepinephrine in the brain that affects feelings and mood.

Most common side effects of nefazodone

Nefazodone's most reported side effects include drowsiness, nausea, dizziness or lightheadedness, weakness, dry mouth, and constipation. Usually, these side effects diminish or disappear within the first few weeks of taking the drug. Taking nefazodone with food can help reduce nausea. Nefazodone appears less likely to cause sexual dysfunction than the selective serotonin reuptake inhibitor antidepressants (SSRIs), which include fluoxetine (Prozac®), sertraline (Zoloft®), paroxetine (Paxil®), citalopram (Celexa®) and fluvoxamine.

Potential risks of children taking antidepressants

There have been recent links to an increased risk of suicide in children taking antidepressants. Be sure to talk to your doctor about the risks and benefits of children taking antidepressants. The brand name Serzone® was voluntarily discontinued by the manufacturer due to life-threatening cases of liver failure. Be sure to talk to your doctor if you have any liver issues and are taking nefazodone. Your doctor may decide to switch you to a different antidepressant.

Read more about depression in our Health Encyclopedia.

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