Mutamycin

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Question

What is Mutamycin (mitomycin)?

Answer

Mutamycin® (mitomycin) is a prescription chemotherapy medication used for cancer treatment. Mutamycin® is indicated for the treatment of stomach and pancreas cancers and used off-label to treat cancers of the bladder, colorectal, lungs, breasts, cervix, head and neck. Mutamycin® slows or stops the growth of cancer cells in your body. The medication comes in the form of a powder for injection that is administered by a doctor through injection into the vein.

What should I know about Mutamycin (mitomycin) before receiving it?

Before receiving Mutamycin® (mitomycin), you should provide your doctors with your complete medical history, including any medications or supplements you are taking, and any medical conditions you have or have ever had. It is especially important to notify your doctors if you have, or have a history of, the following medical conditions: bleeding disorders, low blood platelets or white blood cells, kidney disease, liver disease, infections and shingles or chickenpox, or if you have had radiation. Before receiving Mutamycin®, it is important to tell your doctor if you are breastfeeding, pregnant or plan to become pregnant. Women should not plan a pregnancy while undergoing chemotherapy or following chemotherapy treatments, and should use birth control during this time. Mutamycin® may interfere with a woman's normal menstrual cycle and may halt a man's sperm production. Mutamycin® may decrease bone marrow blood cells and may cause kidney damage. The medication also increases the risk of infection, and so you should not receive any live vaccinations while on Mutamycin®, avoid being around other people with infections and take precautions to avoid infection, such as regularly washing hands.

Does Mutamycin (mitomycin) interact with other medications or foods?

Mutamycin® (mitomycin) may interact with other medications, supplements and foods. The combination of Mutamycin® with certain medications may cause an increase, decrease or altered effect of either medication. Although you should thoroughly discuss with your doctor the potential interactions of all medications you are taking, some medications that are known to adversely interact with Mutamycin® include: aspirin, tamoxifen, vinblastine, as well as many vaccines. Mutamycin® can also interact with vitamins, so be sure to tell your doctor about all supplements, vitamins and herbs you may be taking while on this drug.

What are the side effects of Mutamycin (mitomycin)?

Many people experience side effects while taking Mutamycin® (mitomycin). Common side effects include: nausea, vomiting, weight loss, appetite loss, abdominal pain, dehydration, temporary hair loss or thinness and sores or pain in mouth and throat. You can control nausea and vomiting by eating smaller meals and not eating before treatment. If you continue to have nausea and vomiting, your doctor may prescribe medication to control these symptoms. You can control pain in the throat and mouth by brushing teeth gently and avoiding alcohol-containing mouthwashes. Call your doctor immediately if you experience more serious side effects including black, tarry or bloody stools, bloody vomit or vomit with the appearance of coffee grounds, excessive bruising or bleeding, difficulty breathing, dizziness, edema of feet and ankles, problems with urination, fever, chills, cough, sore throat, swelling and pain at site of injection, rash and itching and severe, persistent fatigue and mouth blistering. Because other side effects may occur, you should notify a doctor about any new symptoms so that a doctor can determine if the symptoms are related to use of Mutamycin®.

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