Online Topical Tretinoin Prescription | Walgreens
Online Topical Tretinoin Prescription
Get tretinoin prescription online, if approved. It’s easy with Walgreens Virtual Healthcare.
Start Your Online Visit with virtual healthcareAvailable in select states*

Understanding Tretinoin
What is tretinoin?1-7
Tretinoin is a synthetic form of vitamin A called a retinoid. It is a topical medication prescribed to treat acne. It’s also used to help improve fine lines and wrinkles, dark spots and rough skin on the face. It is typically used once daily in the evening. Topical tretinoin is available as a gel, cream or lotion. It’s offered in multiple strengths, ranging from 0.01% to 0.1%. Topical tretinoin is also known by the brand names Altreno, Atralin, Renova and Retin-A.
How does tretinoin treat acne?1,6,8
Topical tretinoin treats acne by increasing skin cell turnover, which can help unclog pores and prevent pores from clogging in the future. Tretinoin also boosts collagen which can improve the appearance of the skin. It may also reduce acne blemishes and prevent acne scars from forming. It takes time to see results with topical tretinoin. Skin can often appear worse in the first few weeks, and it may take several months of continuous use to see the full benefits.
What are the possible side effects of tretinoin?5-6,8-9
As with all medications, tretinoin can cause side effects. These may include skin irritation such as skin dryness, redness, burning, itching, discoloration and an increased chance of sunburn. Tretinoin will increase sensitivity to sunlight, so it’s important to protect your skin when using this medication. Whenever possible, cover skin with clothing. Apply a broad-spectrum sunscreen with a sun protection factor (SPF) of 30 or higher to all exposed skin and reapply at least every two hours. Use topical tretinoin with caution on sunburned skin or if you have eczema as it may cause severe irritation.
Some forms of topical tretinoin contain fish proteins. If you have a fish allergy or sensitivity, speak with your healthcare provider to determine which product is safe for you. Topical tretinoin should not be used by those who are pregnant or trying to get pregnant. Seek medical help if you notice any unusual side effects such as severe redness, blistering or swelling of the face. Speak with your healthcare provider about any serious or unexpected side effects you may be experiencing from your medications.
How to use Walgreens Virtual Healthcare to get tretinoin
During your Walgreens Virtual skincare visit, you will start by completing an online questionnaire. On this intake form, you will select if you want to refill your current prescription, change your prescription or start a new medication. You will answer questions about your skincare goals, review your current symptoms, and provide details regarding your medication and health history. A doctor or nurse practitioner will connect with you via secure online chat, and if appropriate, prescribe medication which may be filled at the pharmacy of your choice.
Which strength of topical tretinoin is right for me?1,6
Tretinoin topical gel, cream and lotion are available in multiple strengths ranging from 0.01% to 0.1%. During your Walgreens Virtual Healthcare consultation, your provider will determine if topical tretinoin is appropriate for your symptoms, and if so, which dosage form and strength to prescribe. When first starting or increasing the strength of tretinoin, your skin may become irritated, red and flaky. To help minimize this side effect, your Walgreens Virtual Healthcare provider may choose to start you with a lower strength of tretinoin and increase the concentration as your skin adjusts.
What forms of tretinoin are offered through Walgreens Virtual Healthcare?
Topical tretinoin is available through Walgreens Virtual Healthcare in a cream, gel or lotion form and in strengths ranging from 0.01% to 0.1%. Your Walgreens Virtual Healthcare provider will determine if tretinoin is right for you, and if so, which dosage form and strength.
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Frequently Asked Questions
- How does topical tretinoin work?2,6-5,10
Topical tretinoin can be used to treat acne and to improve the appearance of wrinkles and dark spots.
When used for acne, tretinoin unclogs pores and prevents pores from clogging in the future, reducing the occurrence of pimples. Tretinoin also helps increase skin cell turnover, replacing older skin with new skin. This reduces acne scars and improves the appearance of the skin. Some improvement may be noticeable after two to three weeks. However, it may take over six weeks of therapy to see significant improvements in skin with acne.
As we age, skin cell turnover slows, the skin thins, it retains less moisture and has less elastin and collagen. Topical tretinoin works to improve the appearance of fine lines and wrinkles by slowing down the breakdown of collagen, making skin more elastic. It also increases skin cell turnover, which reduces fine lines and wrinkles, and improves overall skin appearance. Topical tretinoin works deep inside your skin, and it takes time to see results. Generally, you may notice some effects in three to four months. However, it may take up to six months of continuous use to see full anti-aging benefits.
Whether topical tretinoin is used for acne or anti-aging, it is usually prescribed for use once daily in the evening. Tretinoin increases the skin’s sensitivity to the sun, so it works best when paired with a skincare routine that includes sun protection to prevent further damage. If tretinoin is discontinued, acne, scarring and fine lines and winkles may reappear over time.
- Do you need a prescription for tretinoin?2
Yes, a prescription from a healthcare provider is required to get topical tretinoin. It is not available over the counter.
- Retinol vs tretinoin: What’s the difference?5-6,10
Topical retinol and tretinoin are both synthetic forms of vitamin A used to reduce wrinkles, dark spots and acne. Retinol is a topical product available over the counter. It is a weaker compound compared to tretinoin. As a result, it may cause fewer side effects, but it often takes more time to see results. Tretinoin is available only by prescription, and it’s stronger than retinol. Therefore, tretinoin may work faster and more effectively than retinol. However, it can also cause more skin irritation, particularly when first starting treatment or when increasing the dose.
- Does tretinoin help with wrinkles?5,8,11
Yes, tretinoin can help with wrinkles. Topical tretinoin increases collagen production, helping the skin retain moisture and improve elasticity. It can also make the skin appear smoother and reduce the appearance of wrinkles. It is important to note that it may take up to several months of continuous use to notice improvement in fine lines and wrinkles. Also, if topical tretinoin treatment is discontinued, the effects may gradually fade, and fine lines and wrinkles can reappear.
- Does tretinoin help with acne scars?6
Yes, topical tretinoin can help reduce acne scars. Tretinoin increases skin cell turnover. This allows for new cell growth at the site of acne scars, improving overall appearance. However, this improvement will take time. With continuous use, it may take several months to notice a change in acne scars. If topical tretinoin treatment is discontinued, acne scars may gradually reappear.
- Who is eligible for a tretinoin prescription?
Adults ages 18 to 64 who are not currently pregnant or breastfeeding are eligible for a Walgreens Virtual skincare visit. Photos of the front and each side of the face are required for the consultation. During this visit, the provider will assess symptoms and medical history. They will then determine if a tretinoin prescription is appropriate.
- Tretinoin gel vs cream: How do they differ?12
Topical tretinoin is available in various dosage forms, including gels and creams. A provider can help determine which is the best choice, depending on skin type, personal preference and goals of therapy. Topical tretinoin cream is somewhat greasy. When applied to the skin, the cream spreads easily and most is absorbed. It also has a moisturizing effect.
Topical tretinoin gel is often used on oily skin because it is non-greasy, dries quickly, and it produces less shine. However, since it doesn’t have as much of a moisturizing effect as tretinoin cream, it can cause increased skin irritation in the beginning. Oily skin with acne is often best treated with gels, while more sensitive skin may benefit from creams.
References
1. https://www.aad.org/public/everyday-care/skin-care-secrets/anti-aging/retinoid-retinol
2. https://www.mayoclinic.org/drugs-supplements/tretinoin-topical-route/description/drg-20066521
3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/209353s000lbl.pdf
4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/022070lbl.pdf
5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021108s015lbl.pdf
6. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020475s021lbl.pdf
7. https://my.clevelandclinic.org/health/drugs/19424-tretinoin-cream-acne
8. http://www.ncbi.nlm.nih.gov/books/NBK557478/
10. https://my.clevelandclinic.org/health/treatments/23293-retinol
Disclaimers
*Currently available in the following states: AL, AZ, CA, CO, CT, FL, GA, IL, IN, KS, KY, LA, MA, MD, MI, MN, MO, NC, NJ, NV, NY, OH, OK, PA, SC, TN, TX, VA, WA, WI
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Labcorp and Quest staff are not associates, employees and/or agents of Walgreen Co. or any Walgreens subsidiary or affiliated company. Lab service will be a separate fee, price may vary.
Prescription based on medical evaluation and not guaranteed.
Walgreens-affiliated medical practices are independently owned and operated by licensed physicians who provide services using the Walgreens virtual care program telehealth platform. For more information about the relationship between Walgreens and the medical practices click here.
Walgreens Health Medical Group California P.C. is a California professional medical corporation utilizing the fictitious name “Walgreens Health Medical Group California P.C.” pursuant to Cal. Bus. & Prof. Code § 2415. To view the Fictitious Name Permit click here.