Ozempic and Wegovy are brand names for the same medication, semaglutide, and work the same way in your body by mimicking the effects of a natural hormone called glucagon-like peptide -1 (GLP-1). But they’re approved for different uses and are prescribed in different doses.

• Wegovy is approved for weight management in adults and children 12 and older who have obesity or are overweight with a related health issue such as high blood pressure, diabetes, or high cholesterol. It’s used along with healthy eating and physical activity to help you lose weight and keep it off.
• Ozempic is approved to lower blood sugar in adults with type 2 diabetes and to reduce the risk of heart attack or stroke in patients with diabetes and heart disease.

Yes, it is possible to switch from Ozempic to Wegovy, as both medications contain the same active ingredient, semaglutide. However, this change should only happen with your healthcare provider’s guidance. Ozempic is for patients for managing their type 2 diabetes, while Wegovy is specifically for chronic weight management in adults with obesity or those who are overweight with related health issues.

Yes. Wegovy is approved by the FDA for several conditions:

• Weight loss and maintenance in adults and children 12 years and older who have obesity, and in adults who are overweight with at least one related health issue such as high blood pressure or high cholesterol. It is meant to be used along with a reduced-calorie diet and increased physical activity.
• Reduce the risk of serious cardiovascular events, such as heart attack, stroke, and cardiovascular death, in adults with heart disease who are also obese or overweight.
• Treatment of metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate to severe liver fibrosis.

Patients typically begin with a low dose of a GLP-1 agonist medication, which is gradually increased for effective weight loss. The initial months of treatment allow you to adjust to the medication and lifestyle changes while starting to lose weight. Your dosage may be modified over time depending on your weight loss and any side effects you may experience.

Studies show that patients who are obese or overweight using injectable GLP-1 agonist medications for weight loss, combined with diet and exercise, achieve weight loss of approximately 6% of their body weight at 4 months, 9% at 6 months, and 13% at 12 months. The most significant weight loss occurs within the first 6 months, stabilizing after a year, and can be sustained with continued use of the GLP-1 agonist alongside healthy diet and exercise.

You may consider stopping the GLP-1 agonist medication once you reach your goal weight; however, some studies suggest that weight may be regained after discontinuation. Therefore, it is critical to consult your provider before stopping the medication. Following a healthy diet and exercise plan recommended by your healthcare provider will help to maintain your results if you decide to stop.

Some common side effects of Wegovy include nausea, diarrhea, vomiting, constipation, stomach upset, headache, fatigue, dizziness, burping, and low blood pressure. Less common side effects include hair loss and change or loss in taste.

Notify your provider as soon as possible if you experience any of the following rare but serious side effects:

• Change in vision.
• Acute kidney injury – decrease in the amount of urine or swelling of ankles, hands or feet. This can be caused from dehydration due to diarrhea, nausea and vomiting. Be sure to drink fluids to help reduce your chance of dehydration.
• Hypoglycemia (low blood sugar) – dizziness or light-headedness, sweating, shakiness, blurred vision, slurred speech, weakness, anxiety, hunger, headache, irritability or mood changes, confusion or drowsiness, fast heartbeat, feeling jittery.
• Severe dehydration – increased thirst, dry mouth, headache, feeling lightheaded, dark or brown urine.
• Fast or irregular heartbeat.
• Acute gallbladder disease or gallstones – severe pain in your upper stomach, yellowing of skin or eyes, fever, or clay-colored stool.
• Pancreatitis (inflammation of the pancreas) – severe pain in your abdomen that will not go away, sometimes spreading to your back, with or without nausea or vomiting.
• Thyroid C-cell tumor – a new mass or lump in the neck, pain or trouble swallowing, hoarseness, or trouble breathing.
• Depression or suicidal thoughts.
• Pulmonary aspiration during general anesthesia or deep sedation – inform your healthcare provider that you are taking this medication before any surgeries or procedures.

Hypersensitivity or allergic reactions can occur with Wegovy. Stop using Wegovy and get medical help right away if you have any symptoms of a serious allergic reaction including swelling of your face, lips, tongue or throat, severe rash or itching, very rapid heartbeat, problems breathing or swallowing, fainting or feeling dizzy.

Speak with your provider about any questions or concerns you may have about side effects, and they can discuss ways to help reduce them.

Initially, most patients check in monthly so their provider can adjust their medication dosage for the best results. Once weight loss stabilizes, check-ins typically become less frequent – about every 3 to 6 months, depending on your provider’s recommendation. If you need additional support to discuss side effects, dosing, or other questions or concerns, you can request an on-demand visit with a Walgreens Weight Management provider 7 days a week (7 a.m. to 11 p.m. CST).

Yes! To begin the process, you can start a virtual visit through our Walgreens Weight Management service. A provider will review your medical history and current medications to confirm you’re eligible for weight management treatment. If it’s clinically appropriate and safe, your provider can create a personalized treatment plan and may prescribe Wegovy.

Through March 31, 2026, get Wegovy for $199/month for the first two months via an introductory offer from Novo Nordisk, subsequent doses are $349/month, restrictions and exclusions apply†. The cost of the Walgreens Weight Management visits is separate from the cost of medication.

Yes. In addition to Wegovy, Walgreens Weight Management supports several other GLP-1 agonist medications for weight loss such as tirzepatide (Zepbound) and liraglutide (Saxenda). A doctor or nurse practitioner will evaluate which GLP-1 agonist is right for you by considering your unique health factors, including your BMI and medical history, and will recommend what’s most appropriate for your needs.

Semaglutide (Wegovy, Ozempic^‡), tirzepatide (Zepbound), liraglutide (Saxenda)^1-4

• Contraindications:
  • Personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Known serious hypersensitivity to any of the ingredients in the product.
• Warnings and Precautions:
  • Thyroid C-cell tumors have occurred in animal studies; human relevance of this finding has not been determined. Report symptoms of thyroid tumors (e.g., a lump in the neck, hoarseness, dysphagia, or dyspnea) to your healthcare provider.
  • Inflammation of the pancreas (pancreatitis): contact your healthcare provider immediately if you have severe pain in your abdomen that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back.
  • Acute gallbladder disease or problems including gallstones have occurred. Call your healthcare provider if you have any of the following symptoms of gallbladder disease or complications: pain in your upper stomach (abdomen), yellowing of skin or eyes (jaundice), fever, or clay-colored stool.
  • Hypoglycemia (low blood sugar) risk is increased when using a GLP-1 agonist, especially if also taking medications such as insulin or sulfonylureas. Symptoms of low blood sugar may include dizziness or light-headedness, sweating, shakiness, blurred vision, slurred speech, weakness, anxiety, hunger, headache, irritability or mood changes, confusion or drowsiness, fast heartbeat, feeling jittery.
  • Acute kidney injury: diarrhea, nausea, and vomiting may lead to dehydration which may cause kidney problems such as acute kidney injury and, in rare cases, requiring hemodialysis. It is important that you drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.
  • Gastrointestinal adverse reactions, sometimes severe, have been reported. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
  • Hypersensitivity reactions: stop using the GLP-1 agonist and get medical help right away if you have any symptoms of a serious allergic reaction including swelling of your face, lips, tongue or throat, severe rash or itching, very rapid heartbeat, problems breathing or swallowing, fainting or feeling dizzy.
  • Increased heart rate may occur, even when at rest. Tell your healthcare provider if you feel your heart racing or pounding in your chest, lasting for several minutes.
  • Increased risk of pulmonary aspiration (food getting into your lungs) during surgery or other procedures that use anesthesia or deep sedation due to delayed gastric emptying. Tell all your healthcare providers that you are taking this GLP-1 agonist before you are scheduled to have surgery or other procedures.
  • Changes in vision: Tell your healthcare provider if you have changes in vision. A temporary worsening of diabetic retinopathy could occur. (Wegovy, Ozempic, or Zepbound only)
  • Pregnancy and breastfeeding: Speak with your provider if you are or plan to be pregnant or breastfeeding, as these GLP-1 agonists should only be used during pregnancy or breastfeeding if the potential benefit outweighs potential risk to the fetus or breastfed infant.
  • Increased risk of depression or thoughts of suicide: Pay attention to any mental changes, especially sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you. (Wegovy, Zepbound, and Saxenda only)
  • Do not share your medication pen or needles with anyone else. You may give an infection to them or get an infection from them.
• Common Side Effects
  • Wegovy: nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distension, belching, hypoglycemia in patients with type 2 diabetes, flatulence, gastroenteritis, gastroesophageal reflux disease, and nasopharyngitis.
  • Ozempic: nausea, vomiting, diarrhea, abdominal pain and constipation.
  • Zepbound: nausea, diarrhea, vomiting, constipation, abdominal pain, upset stomach, injection site reactions, fatigue, hypersensitivity reactions, belching, hair loss, gastroesophageal reflux disease (GERD).
  • Saxenda: nausea, diarrhea, constipation, vomiting, injection site reactions, headache, low blood sugar, upset stomach, fatigue, dizziness, abdominal pain, increased lipase (a digestive enzyme), upper abdominal pain, fever, and gastroenteritis (inflammation of the stomach and intestines).
• Drug or Food Interactions
  • Delayed gastric emptying may impact absorption of concomitantly administered oral medications.
  • Use of Zepbound may reduce the efficacy of oral hormonal contraceptives. If you are using oral hormonal contraceptives, switch to a non-oral contraceptive method or add a barrier method of contraception for 4 weeks after starting Zepbound and for 4 weeks after each dose increase.
  • Be sure to tell your healthcare provider about all the medications you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. GLP-1 agonist medications can change how some medicines work, and other medicines may affect how GLP-1 medications work too.

Ondansetron (Zofran)**

• Contraindications:
  • Known serious hypersensitivity to any of the ingredients in the product.
  • Concomitant use of apomorphine (brand names Apokyn, Onapgo).
• Warnings and Precautions:
  • Allergies: Do not use ondansetron if you are allergic to it or similar medications. Seek emergency care if you develop swelling of the face, lips, tongue, or throat; trouble breathing or swallowing; severe rash; or fainting.
  • Heart Rhythm Risks (QT Prolongation): Ondansetron can rarely affect heart rhythm. The risk is higher if you have certain heart conditions, low potassium or magnesium, liver disease, or take other QT-prolonging medicines. Tell your provider about all medications you take and your medical history.
  • Serotonin Syndrome: Rare but serious. Seek immediate care for agitation, hallucinations, fast heartbeat, sweating, fever, tremor, stiffness, or coordination problems—especially if taking antidepressants or other serotonergic drugs.
  • Dizziness: May cause sleepiness or light-headedness. Avoid alcohol, marijuana, or driving until you know how it affects you.
  • Digestive Issues: Can disguise symptoms of bowel blockage; report severe abdominal swelling or lack of bowel activity.
  • pecial Populations: Older adults may be more sensitive. Use during pregnancy or breastfeeding only if recommended by your provider. Speak with your provider if you are or plan to be pregnant, as ondansetron should only be used during pregnancy when medically needed. Ondansetron passes into breastmilk – consult your provider before using it if you are or plan to be breastfeeding.
  • Phenylketonuria (PKU): The orally disintegrating tablet contains a small amount of phenylalanine.
• Common Side Effects
  • Headache, fatigue, constipation, and diarrhea.
• Drug or Food Interactions
  • Serotonin Syndrome has been reported with ondansetron alone, and particularly with concomitant use of serotonergic drugs (SSRIs, SNRIs, MAO inhibitors, mirtazapine, tramadol, fentanyl, lithium). Symptoms of serotonin syndrome include mental status changes (agitation, hallucinations, delirium); fast heartbeat, fluctuating blood pressure, dizziness, flushing, sweating; tremor, extremity rigidity, incoordination; seizures. If such symptoms occur, discontinue ondansetron and seek medical help promptly.

^‡Not FDA approved for weight loss.

**Not FDA approved for general nausea/vomiting; FDA approved for chemotherapy-induced, postoperative, radiation therapy-associated nausea and vomiting.