SAM-e (short for S-adenosylmethionine) is a naturally occurring molecule in the body that is commonly associated with brain health and mood. While mood support is definitely a benefit, SAM-e can also play a role in joint health. SAM-e stimulates the synthesis of proteoglycans, which are necessary for the growth and repair of cartilage. Healthy cartilage not only protects your joints, but is also needed to maintain joint comfort. SAM-e is a very delicate compound that reacts quickly in the presence of air and moisture. Look for a SAM-e supplement that is packaged in blister packs, which help promote product effectiveness by limiting environmental exposure. Also, make sure your SAM-e supplement is enteric-coated. An enteric-coated formula means that the product can travel through the stomach to the small intestine where it is best absorbed.