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What can I take to treat a runny, stuffy nose and sinus drainage?


There are a variety of over-the-counter (OTC) products that may be used for a runny or stuffy nose and sinus drainage. The two primary types of these medications include antihistamines and oral decongestants. Products are available as combination products for persons who have more than one symptom.

Antihistamines may be used to treat "runny nose" symptoms and commonly are found in allergy or cough and cold products. Examples of common OTC antihistamines include diphenhydramine, brompheniramine, and chlorpheniramine. They work by blocking histamine, a chemical that is released in the body. Histamine can cause itchy, watery eyes, runny nose, and other symptoms commonly seen with hay fever and other types of allergies. The most common side effect of antihistamines is drowsiness. Certain medications may interact with antihistamines to produce a more sedating effect. These include, but are not limited to, alcohol and central nervous system depressants (for example, sleep aids and medications used to treat anxiety). In addition, antihistamines should be used with caution by persons living with certain medical conditions, including enlarged prostate, urinary problems, and glaucoma. If you have a medical condition other than hay fever or allergies, or currently are taking other medications, please consult your physician or pharmacist before starting therapy with antihistamines.

Decongestants are used to help treat a stuffy or "plugged-up" nose. Decongestants help by reducing swollen mucous membranes and nasal congestion, making it easier to breathe. However, these products should be used with caution by certain persons. Please consult your physician before taking any OTC medication containing decongestants if you have any of the following conditions: diabetes, high blood pressure, heart disease, glaucoma, enlarged prostate or overactive thyroid. In addition, to prevent serious complications, you should not take a decongestant if you are receiving therapy with a medication known as a monoamine oxidase inhibitor (MAOI). As a precaution, always consult your physician before starting any medication.

View antihistamines and decongestants available from

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Answers to questions regarding information about medications or health conditions are not for diagnostic or treatment purposes and are not conclusive as to the presence or absence of any health condition. Consult your physician for diagnosis and treatment of your medical condition. The information provided is not a substitute for medical advice. Advances in medicine may cause this information to become outdated, invalid or subject to debate. Professional opinions and interpretations of the scientific literature may vary. Walgreens' terms of use and general warranty disclaimer apply to all services provided. If you are in need of immediate medical attention, contact your physician, poison control center or emergency medical professional. If you need to speak with a pharmacist for non-emergency matters, contact your local Walgreens pharmacist or call a pharmacist toll-free at 1 (877) 250-5823.

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