Hepatitis B Vaccine

What is hepatitis B?

Hepatitis B is a highly contagious, serious liver disease caused by the hepatitis B virus. It is spread through contact with the blood or other body fluids of an infected person, including contact with objects that could have blood or body fluids on them such as toothbrushes and razors. The hepatitis B virus can cause:

Acute (short-term) illness, the symptoms of which are flu-like and include loss of appetite, tiredness, joint and muscle pain, diarrhea, vomiting and jaundice. Most adults who get hepatitis B have this acute form of hepatitis B, and then get better.

Chronic (long-term) infection which can be very serious, and often leads to liver damage, liver cancer, or death. Babies and young children infected with hepatitis B are more likely to get this chronic form of the disease.

What is the hepatitis B vaccine?

The hepatitis B vaccine is the best way to prevent infection. It is a series of 3 or 4 shots usually given over a 6-to-12 month period. It is given by an injection into the arm muscle of adolescents and adults and thigh muscle of infants and young children. Estimates of long-term protection for those getting the full vaccination (3 or 4 doses) suggest that protection from hepatitis B could last for up to 20 or 30 years and possibly for life.

Who should get the hepatitis B vaccine?

  • All children should get their first dose at birth, with a second dose between 1-2 months of age, and should have completed their vaccine series by 6-18 months of age.
  • Children and adolescents through 18 years of age who did not get the vaccine when they were younger should be vaccinated.
  • Adults at increased risk of acquiring hepatitis B, as well as any person who desires protection from hepatitis B.
  • Persons at increased risk are as follows:
    • Those whose sex partner is infected with hepatitis B
    • Men who have sex with men
    • People who inject street drugs
    • People with more than one sex partner
    • People with chronic liver or kidney disease, or HIV infection
    • People with jobs that expose them to human blood
    • Household contacts of people infected with hepatitis B
    • Residents and staff in institutions for the developmentally disabled
    • Kidney dialysis patients
    • People who travel to countries where hepatitis B is common
    • People under 60 years of age with diabetes

Who should not get the hepatitis B vaccine?

  • Anyone with a life-threatening allergy to baker's yeast, or to any component of the vaccine should not get the hepatitis B vaccine. Tell your provider if you have any serious allergies.
  • Anyone who has had a life-threatening allergic reaction to a previous dose of hepatitis B vaccine should not get another dose.
  • Anyone who is moderately or severely ill should probably wait until they recover.
  • Pregnant women who need protection from hepatitis B may be vaccinated, but should check with their doctor first.

What are the side effects of the hepatitis B vaccine?

Mild-to-moderate problems:

  • Soreness, redness, or swelling where the shot was given
  • Headache, tiredness, fever and loss of appetite

Severe problems (rare):

  • Difficulty breathing
  • Wheezing
  • Hives
  • Pale skin
  • Fast heartbeat
  • Dizziness

Over-the-counter pain relievers such as acetaminophen or ibuprofen can help ease pain and reduce fever.

It's extremely rare for these vaccines to cause serious harm or death. If the person getting the vaccine has a serious reaction, call the doctor or seek immediate medical attention.

The hepatitis B vaccine is available at:

Healthcare Clinic for patients aged 7+.
Walgreens Pharmacy. Ages vary by state.

If you believe you have a medical emergency,  please call 911.

Tell your doctor or a healthcare provider if the person getting the vaccine has any severe allergies.

Call the Centers for Disease Control and Prevention (CDC) at 800-232-4636 or visit www.cdc.gov/vaccines for more vaccine information.


Hamborsky J, Kroger A, Wolfe S, eds. Centers for Disease Control and Prevention (CDC).Epidemiology and Prevention of Vaccine-Preventable Diseases. 13th ed. Washington, DC: Public Health Foundation, 2015.

Vaccine Information Statement: Hepatitis B Vaccine (What You Need to Know) February 2, 2012. http://www.cdc.gov/vaccines/hcp/vis/vis-statements/hep-b.pdf. Accessed June 2016.

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This publication should be used for general educational purposes only and is not intended to be a substitute for professional medical advice. Although it is intended to be accurate, neither Walgreen Co., its subsidiaries or affiliates, nor any other party assumes liability for loss or damage due to reliance on this publication.

* Vaccines subject to availability. State-, age- and health-related restrictions may apply.