Understanding GLP-1 Drugs | Walgreens

Diabetes management & weight loss

 

Your GLP-1 journey starts here

Learn about FDA-approved medications, their benefits, and how they can help you reach your health goals.

What are GLP-1 medications?

GLP-1 stands for glucagon-like peptide-1, a naturally occurring hormone that helps regulate blood sugar, appetite and digestion. The medications used to mimic this hormone are known as GLP-1 receptor agonists, also called GLP-1 agonists or simply GLP-1 medications. These prescriptions help control insulin and blood glucose levels to support healthy weight loss and blood sugar regulation.1

 

When used consistently, GLP-1 medications can signal the brain to feel fuller sooner, slow stomach emptying to reduce hunger, and help the pancreas release insulin after meals, which in turn lowers blood sugar.2

What GLP-1 medications are used for

GLP-1 medications are FDA-approved to treat Type 2 diabetes and obesity, and they’re proven to be effective when used appropriately.3

 

These medications are also gaining popularity for off-label use in weight loss, and ongoing research is exploring their potential to help improve other medical conditions.4,5

FDA-approved GLP-1 medications


FDA-approved for type 2 diabetes
Ozempic® (semaglutide)
Rybelsus® (semaglutide)
Mounjaro® (tirzepatide)
Byetta® (exenatide)
Bydureon® (exenatide)
Trulicity® (dulaglutide)Victoza® (liraglutide)

 

FDA-approved for chronic weight management
Wegovy® (semaglutide)
Zepbound™ (tirzepatide)
Saxenda® (liraglutide)

How to to use your GLP-1 medication

GLP-1 medications are self-injected, often using a pen device that contains a pre-filled dose. Your dose and dosing schedule will depend on your specific medication and treatment plan.

 

Learn how to administer self-injected medications

Choosing the right GLP-1 medication

Although all GLP-1 medications work in similar ways, they’re not all the same. Most are injectables, and dosing can range from daily to weekly, depending on medication and reason for use. Non-injectable versions, including oral pills, are being studied and may be an option in the near future.

 

Your healthcare provider will help you choose the option that best fits your health history, lifestyle, health needs, goals and how you may tolerate the medication. It may take some time to find the right fit. Your provider may start you on a specific dose and adjust it gradually over time to help reduce side effects and find what works best for.6

Most common side effects & risks of GLP-1 medications

GLP-1 medications, like all drugs, can cause side effects. Most side effects are mild, manageable, temporary and dose-related.


Side effects may include:1

 

  • Nausea
  • Constipation or diarrhea
  • Decreased appetite
  • Fatigue
  • Headache
  • Mild injection site irritation (mild itchiness or redness)

 

Other side effects may include: 

 

  • Dizziness
  • Increased heart rate
  • Bloating or indigestion

 

Less common but more serious risks may include:1,2 

 

  • Pancreatitis
  • Gallbladder attacks or gastroparesis
  • Bowel obstruction
  • Kidney issues

When to contact your provider

Although most GLP-1 medication side effects are manageable, some symptoms may indicate a more serious health issue. Call your provider right away if you experience:1,2,7

 

  • Severe stomach pain
  • Persistent nausea or vomiting
  • Dehydration symptoms (dry mouth, dizziness, infrequent urination)
  • Inability to pass gas or move your bowels
  • Signs of an allergic reaction (difficulty breathing or swallowing, wheezing, hives or red rash)

 

Call 911 if you experience a medical emergency, including shortness of breath, wheezing, chest tightness or difficulty swallowing.

Is a GLP-1 right for you?

GLP-1 medications can be a powerful tool to help manage weight and blood sugar if you have diabetes. 

Talk to your provider about using GLP-1 medications if you:1,8

 

  • Have type 2 diabetes and need better control of your blood sugar
  • Are living with obesity and have a related health condition, such as high blood pressure, high cholesterol or sleep apnea
  • Have tried diet and exercise without lasting results
  • Don’t have a history of thyroid cancer or multiple endocrine neoplasia type 2
  • Are not pregnant or planning pregnancy during treatment

 

Your provider will review your medical history, current medications, and health goals to help decide if a GLP-1 medication is right for you.

Frequently asked questions

 

  • Weight loss results vary based on your lifestyle, medication type and dose. However, many people lose between 10–15 percent of their weight with continued GLP-1 medication use and lifestyle changes.9

  • Weight loss results may take time. Although most people experience a change in appetite within the first couple of weeks, noticeable weight loss typically begins in the first 4 or 5 weeks.9

  • Certain GLP-1 medications are FDA-approved for weight management in adults with obesity or who are overweight with weight-related health conditions, not including diabetes. Other GLP-1 medications may also be prescribed off-label for weight loss.4

     

    Talk to your provider to determine if a GLP-1 medication is right for you.

  • No, side effects vary from person to person. Common symptoms such as nausea, diarrhea and constipation are usually manageable and temporary, but not everyone experiences them. Your GLP-1 medication response may depend on the specific medication, your dosage, and how your body adjusts to the medication over time. 

  • Gastrointestinal side effects such as nausea, constipation and diarrhea are common when starting a GLP-1 medication but are usually manageable and temporary. 

     

    Here are some ways to help manage your side effects:10 

     

    • Eat slowly and in smaller portions
    • Stick to bland meals and avoid high-fat, spicy foods
    • Stay hydrated with small, frequent sips of water
    • Avoid eating too close to bedtime

     

    These symptoms often improve as your body adjusts. Talk to your provider if your side effects don’t go away or worsen. They may adjust your dose or recommend additional ways to manage your side effects.

  • GLP-1 medications may be taken long-term to help maintain weight loss and regulate blood sugar, depending on how you tolerate the medication and your health goals.11 Staying consistent with your medication and healthy lifestyle adjustments is important to see lasting results.

     

    How long you stay on GLP-1 medication will depend on your health goals, how your body adjusts to the medication, and provider recommendations. Schedule regular check-ins to track progress, manage your side effects, and create a maintenance plan for long-term success. 

     

    Always talk to your doctor before changing or stopping medication.

  • It’s important to use your GLP-1 medication as prescribed to help you achieve the best results. If you miss a dose, follow the instructions on your specific GLP-1 medication. In some cases, you may be able to take a missed dose within a certain time frame. 

     

    Skipping doses or stopping medication without the help of your provider may lead to adverse effects, such as gastrointestinal discomfort and increased hunger or weight gain.12 Contact your provider if you miss a dose and aren’t sure what to do.

  • GLP-1 medications are most effective when combined with healthy lifestyle changes, such as balanced eating, physical activity and getting enough sleep.

     

    Change doesn’t happen overnight. Small, manageable changes to your daily routine will make a big difference over time. Talk to your provider about how to create a plan that fits your health needs and goals.

  • Yes, switching is something possible and may be appropriate based on your health goals, side effect tolerance, cost or insurance coverage. Always talk to your provider before changing or stopping medication to ensure a safe and effective transition. 

  • Yes, most GLP-1 medications are available at Walgreens with a prescription from your provider. Your pharmacist can help answer questions about availability, insurance coverage, approvals and refills.

If you think you have a medical emergency, call 911.

This page is intended for informational purposes only and should not be viewed as a recommendation, endorsement or guarantee by Walgreens. Walgreens does not provide medical advice or prescribe medication. Always consult a licensed healthcare provider before starting, stopping, or changing any medication.

 

GLP-1 medications prescribed for weight loss without a diabetes diagnosis may be considered off-label. Off-label use means the medication is being prescribed for a purpose not specifically approved by the FDA. Walgreens does not recommend or endorse off-label use of any medication. Talk to your provider about the risks and benefits.

Sources: 
 

1 Cleveland Clinic Health Library. GLP-1 Agonists. Cleveland Clinic. Reviewed July 3, 2023. Accessed June 4, 2025. https://my.clevelandclinic.org/health/treatments/13901-glp-1-agonists.


2 Catanese L. GLP-1 diabetes and weight-loss drug side effects: “Ozempic face” and more. Harvard Health Publishing. Published February 5, 2024. Accessed June 4, 2025. https://www.health.harvard.edu/staying-healthy/glp-1-diabetes-and-weight-loss-drug-side-effects-ozempic-face-and-more.


3 Alfaris N, Waldrop S, Johnson V, Boaventura B, Kendrick K, Stanford FC. GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: A narrative review. eClinicalMedicine. 2024;75:102782. doi:10.1016/j.eclinm.2024.102782.
 

4 Han SH, Safeek R, Ockerman K, et al. Public interest in the off-label use of glucagon-like peptide 1 agonists (Ozempic) for cosmetic weight loss: A Google trends analysis. Aesthetic Surgery Journal. 2023;44(1):60–67. doi:10.1093/asj/sjad211.
 

5 Jensen SBK, Blond MB, Sandsdal RM, et al. Healthy weight loss maintenance with exercise, GLP-1 receptor agonist, or both combined followed by one year without treatment: A post-treatment analysis of a randomised placebo-controlled trial. eClinicalMedicine. 2024;69:102475. doi:10.1016/j.eclinm.2024.102475.
 

6 Latif W, Lambrinos KJ, Patel P, Rodriguez R. Compare and contrast the glucagon-like peptide-1 receptor agonists (GLP1RAs). National Library of Medicine. Updated February 25, 2024. Accessed June 4, 2025. https://www.ncbi.nlm.nih.gov/books/NBK572151/.
 

7 Filippatos TD, Panagiotopoulou TV, Elisaf MS. Adverse effects of GLP-1 receptor agonists. The Review of Diabetic Studies. 2014;11(3–4):202–230. doi:10.1900/RDS.2014.11.202.
 

8 Kelly CA, Sipos JA. Approach to the patient with thyroid nodules: Considering GLP-1 receptor agonists. The Journal of Clinical Endocrinology and Metabolism. 2025;110(6):e2080–e2087. doi:10.1210/clinem/dgae722.
 

9 Wilding JPH, Batterham RL, Calanna S, et al. Once-weekly semaglutide in adults with overweight or obesity. The New England Journal of Medicine. 2021;384(11):989–1002. doi:10.1056/NEJMoa2032183.
 

10 Gorgojo-Martínez JJ, Mezquita-Raya P, Carretero-Gómez J, et al. Clinical recommendations to manage gastrointestinal adverse events in patients treated with GLP-1 receptor agonists: A multidisciplinary expert consensus. Journal of Clinical Medicine. 2022;12(1):145. doi:10.3390/jcm12010145.
 

11 Huang YN, Liao WL, Huang JY, et al. Long-term safety and efficacy of glucagon-like peptide-1 receptor agonists in individuals with obesity and without type 2 diabetes: A global retrospective cohort study [published correction appears in Diabetes Obes Metab. 2025 Mar;27(3):1630. doi: 10.1111/dom.16204.]. Diabetes Obes Metab. 2024;26(11):5222-5232. doi:10.1111/dom.15869.
 

12 UCLA Health. Missed a dose (or more) of your GLP-1 medication? Here’s what to do. Published January 6, 2025. Accessed June 4, 2025. https://www.uclahealth.org/news/article/missed-dose-or-more-your-glp-1-medication-heres-what-do.